Recovery from unrecognized sleep loss accumulated in daily life improved mood regulation via prefrontal suppression of amygdala activity

Yuki Motomura, Shingo Kitamura, Kyoko Nakazaki, Kentaro Oba, Ruri Katsunuma, Yuri Terasawa, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Many modern people suffer from sleep debt that has accumulated in everyday life but is not subjectively noticed [potential sleep debt (PSD)]. Our hypothesis for this study was that resolution of PSD through sleep extension optimizes mood regulation by altering the functional connectivity between the amygdala and prefrontal cortex. Fifteen healthy male participants underwent an experiment consisting of a baseline (BL) evaluation followed by two successive interventions, namely, a 9-day sleep extension followed by one night of total sleep deprivation (TSD). Tests performed before and after the interventions included a questionnaire on negative mood and neuroimaging with arterial spin labeling MRI for evaluating regional cerebral blood flow (rCBF) and functional connectivity. Negative mood and amygdala rCBF were significantly reduced after sleep extension compared with BL. The amygdala had a significant negative functional connectivity with the medial prefrontal cortex (FCamg-MPFC), and this negative connectivity was greater after sleep extension than at BL. After TSD, these indices reverted to the same level as at BL. An additional path analysis with structural equation modeling showed that the FCamg-MPFC significantly explained the amygdala rCBF and that the amygdala rCBF significantly explained the negative mood. These findings suggest that the use of our sleep extension protocol normalized amygdala activity via negative amygdala-MPFC functional connectivity. The resolution of unnoticed PSD may improve mood by enhancing frontal suppression of hyperactivity in the amygdala caused by PSD accumulating in everyday life.

Original languageEnglish
Article number306
JournalFrontiers in Neurology
Volume8
Issue numberJUN
DOIs
Publication statusPublished - Jun 30 2017

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Amygdala
Sleep
Cerebrovascular Circulation
Regional Blood Flow
Sleep Deprivation
Prefrontal Cortex
Neuroimaging
Healthy Volunteers

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Recovery from unrecognized sleep loss accumulated in daily life improved mood regulation via prefrontal suppression of amygdala activity. / Motomura, Yuki; Kitamura, Shingo; Nakazaki, Kyoko; Oba, Kentaro; Katsunuma, Ruri; Terasawa, Yuri; Hida, Akiko; Moriguchi, Yoshiya; Mishima, Kazuo.

In: Frontiers in Neurology, Vol. 8, No. JUN, 306, 30.06.2017.

Research output: Contribution to journalArticle

Motomura, Yuki ; Kitamura, Shingo ; Nakazaki, Kyoko ; Oba, Kentaro ; Katsunuma, Ruri ; Terasawa, Yuri ; Hida, Akiko ; Moriguchi, Yoshiya ; Mishima, Kazuo. / Recovery from unrecognized sleep loss accumulated in daily life improved mood regulation via prefrontal suppression of amygdala activity. In: Frontiers in Neurology. 2017 ; Vol. 8, No. JUN.
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