Recovery of decreased seizure threshold for pentylenetehazole during diazepam withdrawal by NMDA receptor antagonists

Tsuda Makoto, Tsutomu Suzuki, Miwa Misawa

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of several NMDA receptor antagonists on pentylenetetrazole-induced diazepam-withdrawal seizure were examined in mice. The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil. Furthermore, MK-801 and ifenprodil, at doses which did not affect the threshold of pentylenetetrazole-induced seizure in control mice, also significantly suppressed the decrease in the seizure threshold during diazepam withdrawal, whereas 7-chlorokynurenic acid did not. These findings suggest that overactivity of an ion channel site and an ifenprodil binding site on the NMDA receptor may play an important role in the hypersensitivity of pentylenetetrazole-induced seizure in diazepam-withdrawn mice.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalEuropean Journal of Pharmacology
Volume324
Issue number1
DOIs
Publication statusPublished - Apr 11 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

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