Rectal cancer in a patient with Bartter syndrome: A case report

Shiki Fujino; Norikatsu Miyoshi; Masayuki Ohue; Mikio Mukai; Yoji Kukita; Taishi Hata; Chu Matsuda; Tsunekazu Mizushima; Yuichiro Doki; Masaki Mori

doi:10.3390/genes8050139

Rectal cancer in a patient with Bartter syndrome: A case report

Shiki Fujino, Norikatsu Miyoshi, Masayuki Ohue, Mikio Mukai, Yoji Kukita, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori

Research output: Contribution to journal › Article › peer-review

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Abstract

A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient’s BS, which became more manageable after tumor resection.

Original language	English
Article number	139
Journal	Genes
Volume	8
Issue number	5
DOIs	https://doi.org/10.3390/genes8050139
Publication status	Published - May 12 2017
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/genes8050139

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title = "Rectal cancer in a patient with Bartter syndrome: A case report",

abstract = "A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient{\textquoteright}s BS, which became more manageable after tumor resection.",

author = "Shiki Fujino and Norikatsu Miyoshi and Masayuki Ohue and Mikio Mukai and Yoji Kukita and Taishi Hata and Chu Matsuda and Tsunekazu Mizushima and Yuichiro Doki and Masaki Mori",

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doi = "10.3390/genes8050139",

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T1 - Rectal cancer in a patient with Bartter syndrome

T2 - A case report

AU - Fujino, Shiki

AU - Miyoshi, Norikatsu

AU - Ohue, Masayuki

AU - Mukai, Mikio

AU - Kukita, Yoji

AU - Hata, Taishi

AU - Matsuda, Chu

AU - Mizushima, Tsunekazu

AU - Doki, Yuichiro

AU - Mori, Masaki

PY - 2017/5/12

Y1 - 2017/5/12

N2 - A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient’s BS, which became more manageable after tumor resection.

AB - A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient’s BS, which became more manageable after tumor resection.

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M1 - 139

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Rectal cancer in a patient with Bartter syndrome: A case report

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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