Rectal cancer in a patient with Bartter syndrome: A case report

Shiki Fujino, Norikatsu Miyoshi, Masayuki Ohue, Mikio Mukai, Yoji Kukita, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities. The PGE2 level is reportedly increased in colorectal cancer, and in the present case, immunohistochemical examination revealed an increased PGE2 level in the tumor. We concluded that the tumor-related PGE2 elevation had worsened the patient’s BS, which became more manageable after tumor resection.

Original languageEnglish
Article number139
JournalGenes
Volume8
Issue number5
DOIs
Publication statusPublished - May 12 2017
Externally publishedYes

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Fujino, S., Miyoshi, N., Ohue, M., Mukai, M., Kukita, Y., Hata, T., ... Mori, M. (2017). Rectal cancer in a patient with Bartter syndrome: A case report. Genes, 8(5), [139]. https://doi.org/10.3390/genes8050139