Recurrent pneumococcal meningitis in a patient with transient IgG subclass deficiency

SHOUICHI OHGA, KENJI OKADA, TAKAHIRO ASAHI, KOHJI UEDA, YUKIO SAKIYAMA, SHUZO MATSUMOTO

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17 Citations (Scopus)

Abstract

We report the case of a 3 year old boy who exhibited recurrent serious infections with a transient imbalance of IgG subclass in the second year of life. He suffered from pneumococcal meningitis at 3 months, hepatitis at 9 months, and purulent arthritis at 11 months of age. The second episode of pneumococcal meningitis occurred at 14 months. Serum IgG level was normal for age. Low level of IgG2, undetectable level of IgG4 and negligible level of pneumococcus‐specific IgG1‐G2 antibodies were found. No other primary immunodeficiency was apparent. Serum IgG2‐G4 levels but not pneumococcus‐specific IgG1‐G2 titers increased by the age of 30 months. At that time, he was inoculated with a polyvalent pneumococcal vaccine along with acellular diphtheria‐pertussis‐tetanus vaccine. He acquired the immunity against these agents, and had no episodic infections in the following 2 years. This observation stresses the existence of transient IgG subclass deficiency associated with delayed development of the anti‐polysaccharide antibody response. 1995 Japan Pediatric Society

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalPediatrics International
Volume37
Issue number2
DOIs
Publication statusPublished - Apr 1995

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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