TY - GEN
T1 - Red blood cell deformability checker with water/plasma pressure transmitter
AU - Monzawa, Takumi
AU - Sakuma, Shinya
AU - Arai, Fumihito
AU - Kaneko, Makoto
N1 - Publisher Copyright:
© 14CBMS.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - A system for evaluating deformability of red blood cells (RBCs) from whole blood is proposed and tested. From previous studies, it is known that RBC characteristics are significantly changed under different liquids, such as plasma, saline, PBS or MAP. Since the plasma of blood is the most natural and friendly environment for RBCs, it would be the best if RBCs can be evaluated in plasma. For this purpose, we developed a new on chip system for evaluating whole blood directly. The plasma is firstly separate from whole blood by a sub stream, and later join the main stream again dilute RBC for achieving single cell evaluation. The deformability index based on cell size change is utilized for the evaluation. The pressure transmitter is used for manipulating RBCs with avoiding mixing between plasma and actuating fluid. From the experiment, we successfully evaluate RBCs without using any artificial buffer.
AB - A system for evaluating deformability of red blood cells (RBCs) from whole blood is proposed and tested. From previous studies, it is known that RBC characteristics are significantly changed under different liquids, such as plasma, saline, PBS or MAP. Since the plasma of blood is the most natural and friendly environment for RBCs, it would be the best if RBCs can be evaluated in plasma. For this purpose, we developed a new on chip system for evaluating whole blood directly. The plasma is firstly separate from whole blood by a sub stream, and later join the main stream again dilute RBC for achieving single cell evaluation. The deformability index based on cell size change is utilized for the evaluation. The pressure transmitter is used for manipulating RBCs with avoiding mixing between plasma and actuating fluid. From the experiment, we successfully evaluate RBCs without using any artificial buffer.
UR - http://www.scopus.com/inward/record.url?scp=84941712288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941712288&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84941712288
T3 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
SP - 1181
EP - 1183
BT - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PB - Chemical and Biological Microsystems Society
T2 - 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Y2 - 26 October 2014 through 30 October 2014
ER -