Red blood cell deformability checker with water/plasma pressure transmitter

Takumi Monzawa, Shinya Sakuma, Fumihito Arai, Makoto Kaneko

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A system for evaluating deformability of red blood cells (RBCs) from whole blood is proposed and tested. From previous studies, it is known that RBC characteristics are significantly changed under different liquids, such as plasma, saline, PBS or MAP. Since the plasma of blood is the most natural and friendly environment for RBCs, it would be the best if RBCs can be evaluated in plasma. For this purpose, we developed a new on chip system for evaluating whole blood directly. The plasma is firstly separate from whole blood by a sub stream, and later join the main stream again dilute RBC for achieving single cell evaluation. The deformability index based on cell size change is utilized for the evaluation. The pressure transmitter is used for manipulating RBCs with avoiding mixing between plasma and actuating fluid. From the experiment, we successfully evaluate RBCs without using any artificial buffer.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages1181-1183
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Externally publishedYes
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Fingerprint Dive into the research topics of 'Red blood cell deformability checker with water/plasma pressure transmitter'. Together they form a unique fingerprint.

Cite this