Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2

Noor Dina Muhd Noor, Hiroaki Matsuura, Koji Nishikawa, Hulin Tai, Shun Hirota, Jaehyun Kim, Jiyoung Kang, Masaru Tateno, Ki Seok Yoon, Seiji Ogo, Shintaro Kubota, Yasuhito Shomura, Yoshiki Higuchi

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Citrobacter sp. S-77 [NiFe]-hydrogenase harbors a standard [4Fe-4S] cluster proximal to the Ni-Fe active site. The presence of relocatable water molecules and a flexible aspartate enables the [4Fe-4S] to display redox-dependent conformational changes. These structural features are proposed to be the key aspects that protect the active site from O2 attack.

    Original languageEnglish
    Pages (from-to)12385-12388
    Number of pages4
    JournalChemical Communications
    Volume54
    Issue number87
    DOIs
    Publication statusPublished - 2018

    All Science Journal Classification (ASJC) codes

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

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