Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2

Noor Dina Muhd Noor, Hiroaki Matsuura, Koji Nishikawa, Hulin Tai, Shun Hirota, Jaehyun Kim, Jiyoung Kang, Masaru Tateno, Ki Seok Yoon, Seiji Ogo, Shintaro Kubota, Yasuhito Shomura, Yoshiki Higuchi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Citrobacter sp. S-77 [NiFe]-hydrogenase harbors a standard [4Fe-4S] cluster proximal to the Ni-Fe active site. The presence of relocatable water molecules and a flexible aspartate enables the [4Fe-4S] to display redox-dependent conformational changes. These structural features are proposed to be the key aspects that protect the active site from O2 attack.

Original languageEnglish
Pages (from-to)12385-12388
Number of pages4
JournalChemical Communications
Volume54
Issue number87
DOIs
Publication statusPublished - Jan 1 2018

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All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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