Redox molecular imaging using ReMI

Fuminori Hyodo, Shinji Ito, Hideo Utsumi

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Abstract

Tissue redox status is one of the most important parameters to maintain homeostasis in the living body. Numerous redox reactions are involved in metabolic processes, such as energy production in the mitochondrial electron transfer system. A variety of intracellular molecules such as reactive oxygen species, glutathione, thioredoxins, NADPH, ‰avins, and ascorbic acid may contribute to the overall redox status in tissues. Breakdown of redox balance may lead to oxida- tive stress and can induce many pathological conditions such as cancer, neurological disorders, and aging. Therefore im- aging of tissue redox status and monitoring antioxidant levels in living organisms can be useful in the diagnosis of dis- ease states and assessment of treatment response. In vivo redox molecular imaging technology such as electron spin resonance imaging (ESRI), magnetic resonance imaging (MRI), and dynamic nuclear polarization (DNP)-MRI (redox molecular imaging; ReMI) is emerging as a viable redox status imaging modality. This review focuses on the application of magnetic resonance technologies using MRI or DNP-MRI and redox-sensitive contrast agents.

Original languageEnglish
Pages (from-to)725-731
Number of pages7
JournalYakugaku Zasshi
Volume135
Issue number5
DOIs
Publication statusPublished - Jan 1 2015

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Hyodo, F., Ito, S., & Utsumi, H. (2015). Redox molecular imaging using ReMI. Yakugaku Zasshi, 135(5), 725-731. https://doi.org/10.1248/yakushi.14-00235-2