Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

Motohiro Nishida, Akiyuki Nishimura, Tetsuro Matsunaga, Hozumi Motohashi, Shingo Kasamatsu, Takaaki Akaike

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.

Original languageEnglish
Pages (from-to)132-140
Number of pages9
JournalFree Radical Biology and Medicine
Volume109
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Metabolism
Oxidation-Reduction
Nitric Oxide
Cardiovascular Physiological Phenomena
Cell signaling
Environmental Pollutants
Biosynthesis
Physiology
Reactive Oxygen Species
Cardiovascular Diseases
Derivatives
Food
persulfides
Research
8-nitroguanosine 3',5'-cyclic monophosphate
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology (medical)

Cite this

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells. / Nishida, Motohiro; Nishimura, Akiyuki; Matsunaga, Tetsuro; Motohashi, Hozumi; Kasamatsu, Shingo; Akaike, Takaaki.

In: Free Radical Biology and Medicine, Vol. 109, 01.08.2017, p. 132-140.

Research output: Contribution to journalReview article

Nishida, Motohiro ; Nishimura, Akiyuki ; Matsunaga, Tetsuro ; Motohashi, Hozumi ; Kasamatsu, Shingo ; Akaike, Takaaki. / Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells. In: Free Radical Biology and Medicine. 2017 ; Vol. 109. pp. 132-140.
@article{28bea2a0974e465ba7bd9e2842fe1779,
title = "Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells",
abstract = "Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.",
author = "Motohiro Nishida and Akiyuki Nishimura and Tetsuro Matsunaga and Hozumi Motohashi and Shingo Kasamatsu and Takaaki Akaike",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.freeradbiomed.2017.01.024",
language = "English",
volume = "109",
pages = "132--140",
journal = "Free Radical Biology and Medicine",
issn = "0891-5849",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells

AU - Nishida, Motohiro

AU - Nishimura, Akiyuki

AU - Matsunaga, Tetsuro

AU - Motohashi, Hozumi

AU - Kasamatsu, Shingo

AU - Akaike, Takaaki

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.

AB - Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.

UR - http://www.scopus.com/inward/record.url?scp=85009956056&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009956056&partnerID=8YFLogxK

U2 - 10.1016/j.freeradbiomed.2017.01.024

DO - 10.1016/j.freeradbiomed.2017.01.024

M3 - Review article

VL - 109

SP - 132

EP - 140

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

ER -