TY - JOUR
T1 - Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells
AU - Nishida, Motohiro
AU - Nishimura, Akiyuki
AU - Matsunaga, Tetsuro
AU - Motohashi, Hozumi
AU - Kasamatsu, Shingo
AU - Akaike, Takaaki
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (16KT0013 to M.N. and T.A.; 15K18883 to A.N.; and 25253020 to T.A.), and Grants-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) (26111008, 26111001 to T.A.), from the Ministry of Education, Culture, Sports, Science and Technology (MEXT). This work was also supported by PRESTO, Japan Science and Technology Agency (JST).
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/8
Y1 - 2017/8
N2 - Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.
AB - Maintaining a redox balance by means of precisely controlled systems that regulate production, and elimination, and metabolism of electrophilic substances (electrophiles) is essential for normal cardiovascular function. Electrophilic signaling is mainly regulated by endogenous electrophiles that are generated from reactive oxygen species, nitric oxide, and the derivative reactive species of nitric oxide during stress responses, as well as by exogenous electrophiles including compounds in foods and environmental pollutants. Among electrophiles formed endogenously, 8-nitroguanosine 3’,5’-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive persulfide species such as cysteine persulfides and polysulfides that are endogenously produced in cells are likely to be involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cardiovascular physiology and pathophysiology. In our review, we focus on the redox-dependent regulation of electrophilic signaling via reduction and metabolism of electrophiles by reactive persulfides in cardiac cells, and we include suggestions for a new therapeutic strategy for cardiovascular disease.
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U2 - 10.1016/j.freeradbiomed.2017.01.024
DO - 10.1016/j.freeradbiomed.2017.01.024
M3 - Review article
C2 - 28109891
AN - SCOPUS:85009956056
SN - 0891-5849
VL - 109
SP - 132
EP - 140
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -
