Redox regulation of the actin cytoskeleton and its role in the vascular system

Qian Xu, Lauren P. Huff, Masakazu Fujii, Kathy K. Griendling

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)

Abstract

The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical, organizational and signaling roles. Because many cytoskeletal proteins are sensitive to reactive oxygen species, redox regulation has emerged as a pivotal modulator of the actin cytoskeleton and its associated proteins. Here, we summarize work implicating oxidants in altering actin cytoskeletal proteins and focus on how these alterations affect cell migration, proliferation and contraction of vascular cells. Finally, we discuss the role of oxidative modification of the actin cytoskeleton in vivo and highlight its importance for vascular diseases.

Original languageEnglish
Pages (from-to)84-107
Number of pages24
JournalFree Radical Biology and Medicine
Volume109
DOIs
Publication statusPublished - Aug 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology (medical)

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