Reduced amount of secretory component of IgA secretion in tears of patients with atopic dermatitis

Akito Toshitani, Shuhei Imayama, Yuji Shimozono, Takaaki Yoshinaga, Masutaka Furue, Yoshiaki Hori

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Coupled with the previous finding that sIgA excretion was reduced onto the surface of the skin, we demonstrated that sIgA secretion in the tears of patients with atopic dermatitis (AD) was significantly lower than that of normal subjects, using a small stick made of nitrocellulose membrane. In the bacterial cultures, we have also detected a higher frequency of Staphylococcus aureus in the tears from patients with AD compared to normal subjects. These findings suggested reduced sIgA secretion on the mucous membrane might play a crucial role in the pathomechanisms of the ocular lesions, such as abnormal bacterial flora and ocular complications as well as the establishment of skin lesions in AD.

Original languageEnglish
Pages (from-to)134-138
Number of pages5
JournalJournal of Dermatological Science
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

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