Reduced expression of catenin subtypes is a potential indicator of unfavorable prognosis in esophageal squamous cell carcinoma

Tadahiro Nozoe, Tsunehiro Oyama, Hidetaka Uramoto, Mistuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Catenins are cytoplasmic proteins that play a pivotal role in cell adhesion. Conflicting results regarding the significance of their expression in esophageal squamous cell carcinoma (ESCC) have been reported. The expression of α-, β- and γ-catenin was examined using immunohistochemical methods in 69 samples collected from patients with ESCC who were surgically treated without any preoperative induction therapy. Reduced α-, β- and γ-catenin expression was observed in 48 (69.7%), 36 (52.2%) and 44 (63.8%) ESCC samples, respectively. According to univariate analysis, ESCC patients exhibiting the reduced expression of β-catenin (P=0.028), γ-catenin (P=0.010), α- and γ-catenin combined (P=0.047) or β- and γ-catenin combined (P=0.046) had a significantly more unfavorable rate of survival. Multivariate analysis demonstrated that the reduced expression of γ-catenin (P=0.015) as well as lymph node metastasis (P=0.015) could serve as independent prognostic indicators of unfavorable prognosis in ESCC patients. Reduced immunohistochemical expression of γ-catenin may thus prove to be a powerfull and useful predictor of prognosis in patients with ESCC.

Original languageEnglish
Pages (from-to)353-357
Number of pages5
JournalMolecular Medicine Reports
Volume2
Issue number3
DOIs
Publication statusPublished - Aug 31 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

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