Reduced expression of focal adhesion kinase in intrahepatic cholangiocarcinoma is associated with poor tumor differentiation

Ryuji Ohta, Yo Ichi Yamashita, Akinobu Taketomi, Dai Kitagawa, Yosuke Kuroda, Shinji Itoh, Shin Ichi Aishima, Yoshihiko Maehara

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Abstract

Objective: Focal adhesion kinase (FAK) expression has been linked to tumor cell invasion and metastasis, but its role in intrahepatic cholangiocarcinoma (ICC) has not been addressed. The goal of this study was to investigate FAK expression in ICC and to assess whether its expression is correlated with clinicopathological factors or prognosis in patients with ICC. Methods: FAK expression was examined using immunohistochemistry with sections from 56 resected ICC specimens. The correlations between FAK expression and clinical outcome were assessed. Results: The patients were divided into two groups according to the degree of FAK expression: high FAK group (n = 16) and low FAK group (n = 40). A lower expression of FAK was correlated with tumor size, poor differentiation, lymph node metastasis, vascular invasion, and intrahepatic metastasis. In the low FAK expression group, multiple recurrence and distant metastases were more prevalent than in the high FAK expression group. The overall and disease-free survival analysis indicated worse outcomes of the low FAK expression group (p < 0.01). Conclusions: A low expression of FAK in ICC is associated with a poor outcome after a surgical resection.

Original languageEnglish
Pages (from-to)417-422
Number of pages6
JournalOncology
Volume71
Issue number5-6
DOIs
Publication statusPublished - Oct 1 2007

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Focal Adhesion Protein-Tyrosine Kinases
Cholangiocarcinoma
Neoplasms
Neoplasm Metastasis
Survival Analysis
Disease-Free Survival
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Reduced expression of focal adhesion kinase in intrahepatic cholangiocarcinoma is associated with poor tumor differentiation. / Ohta, Ryuji; Yamashita, Yo Ichi; Taketomi, Akinobu; Kitagawa, Dai; Kuroda, Yosuke; Itoh, Shinji; Aishima, Shin Ichi; Maehara, Yoshihiko.

In: Oncology, Vol. 71, No. 5-6, 01.10.2007, p. 417-422.

Research output: Contribution to journalArticle

Ohta, R, Yamashita, YI, Taketomi, A, Kitagawa, D, Kuroda, Y, Itoh, S, Aishima, SI & Maehara, Y 2007, 'Reduced expression of focal adhesion kinase in intrahepatic cholangiocarcinoma is associated with poor tumor differentiation', Oncology, vol. 71, no. 5-6, pp. 417-422. https://doi.org/10.1159/000107109
Ohta, Ryuji ; Yamashita, Yo Ichi ; Taketomi, Akinobu ; Kitagawa, Dai ; Kuroda, Yosuke ; Itoh, Shinji ; Aishima, Shin Ichi ; Maehara, Yoshihiko. / Reduced expression of focal adhesion kinase in intrahepatic cholangiocarcinoma is associated with poor tumor differentiation. In: Oncology. 2007 ; Vol. 71, No. 5-6. pp. 417-422.
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abstract = "Objective: Focal adhesion kinase (FAK) expression has been linked to tumor cell invasion and metastasis, but its role in intrahepatic cholangiocarcinoma (ICC) has not been addressed. The goal of this study was to investigate FAK expression in ICC and to assess whether its expression is correlated with clinicopathological factors or prognosis in patients with ICC. Methods: FAK expression was examined using immunohistochemistry with sections from 56 resected ICC specimens. The correlations between FAK expression and clinical outcome were assessed. Results: The patients were divided into two groups according to the degree of FAK expression: high FAK group (n = 16) and low FAK group (n = 40). A lower expression of FAK was correlated with tumor size, poor differentiation, lymph node metastasis, vascular invasion, and intrahepatic metastasis. In the low FAK expression group, multiple recurrence and distant metastases were more prevalent than in the high FAK expression group. The overall and disease-free survival analysis indicated worse outcomes of the low FAK expression group (p < 0.01). Conclusions: A low expression of FAK in ICC is associated with a poor outcome after a surgical resection.",
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AU - Ohta, Ryuji

AU - Yamashita, Yo Ichi

AU - Taketomi, Akinobu

AU - Kitagawa, Dai

AU - Kuroda, Yosuke

AU - Itoh, Shinji

AU - Aishima, Shin Ichi

AU - Maehara, Yoshihiko

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N2 - Objective: Focal adhesion kinase (FAK) expression has been linked to tumor cell invasion and metastasis, but its role in intrahepatic cholangiocarcinoma (ICC) has not been addressed. The goal of this study was to investigate FAK expression in ICC and to assess whether its expression is correlated with clinicopathological factors or prognosis in patients with ICC. Methods: FAK expression was examined using immunohistochemistry with sections from 56 resected ICC specimens. The correlations between FAK expression and clinical outcome were assessed. Results: The patients were divided into two groups according to the degree of FAK expression: high FAK group (n = 16) and low FAK group (n = 40). A lower expression of FAK was correlated with tumor size, poor differentiation, lymph node metastasis, vascular invasion, and intrahepatic metastasis. In the low FAK expression group, multiple recurrence and distant metastases were more prevalent than in the high FAK expression group. The overall and disease-free survival analysis indicated worse outcomes of the low FAK expression group (p < 0.01). Conclusions: A low expression of FAK in ICC is associated with a poor outcome after a surgical resection.

AB - Objective: Focal adhesion kinase (FAK) expression has been linked to tumor cell invasion and metastasis, but its role in intrahepatic cholangiocarcinoma (ICC) has not been addressed. The goal of this study was to investigate FAK expression in ICC and to assess whether its expression is correlated with clinicopathological factors or prognosis in patients with ICC. Methods: FAK expression was examined using immunohistochemistry with sections from 56 resected ICC specimens. The correlations between FAK expression and clinical outcome were assessed. Results: The patients were divided into two groups according to the degree of FAK expression: high FAK group (n = 16) and low FAK group (n = 40). A lower expression of FAK was correlated with tumor size, poor differentiation, lymph node metastasis, vascular invasion, and intrahepatic metastasis. In the low FAK expression group, multiple recurrence and distant metastases were more prevalent than in the high FAK expression group. The overall and disease-free survival analysis indicated worse outcomes of the low FAK expression group (p < 0.01). Conclusions: A low expression of FAK in ICC is associated with a poor outcome after a surgical resection.

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