Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma

Yasushi Toh, Shinji Kuninaka, Masaki Mori, Tatsuro Oshiro, Yasuharu Ikeda, Hideaki Nakashima, Hideo Baba, Shunji Kohnoe, Takeshi Okamura, Keizo Sugimachi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the corresponding normal mucosal tissues by reverse transcription-polymerase chain reaction. The tumor/normal (T/N) ratio of 45 patients with esophageal carcinoma was calculated, and the data were clinicopathologically analyzed. The T/N ratio of Mn-SOD mRNA expression was less than 0.5 in 11 (32.4%) of 34 esophageal carcinoma cases without any preoperative treatments, while none of 11 cases who underwent preoperative chemotherapy showed a T/N ratio of <0.5 (p < 0.05). There was an inverse correlation between the Mn-SOD expression level and the degree of venous invasion (p < 0.05) as well as lymphatic invasion (p < 0.05). Furthermore, poorly differentiated squamous cell carcinoma showed significantly lower Mn-SOD mRNA expression levels than well differentiated carcinoma (p < 0.05). Our results suggest that Mn-SOD mRNA was frequently reduced in esophageal carcinoma when compared to the normal mucosa and the reduced expression levels of Mn-SOD mRNA may lead to an accumulation of superoxide radicals in conjunction with the increased invasiveness of esophageal carcinoma. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalOncology
Volume59
Issue number3
DOIs
Publication statusPublished - Jan 1 2000

Fingerprint

Superoxide Dismutase
Carcinoma
Messenger RNA
Mucous Membrane
Neoplasms
Superoxides
Reverse Transcription
Squamous Cell Carcinoma
Antioxidants
Drug Therapy
Polymerase Chain Reaction
Esophageal Squamous Cell Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma. / Toh, Yasushi; Kuninaka, Shinji; Mori, Masaki; Oshiro, Tatsuro; Ikeda, Yasuharu; Nakashima, Hideaki; Baba, Hideo; Kohnoe, Shunji; Okamura, Takeshi; Sugimachi, Keizo.

In: Oncology, Vol. 59, No. 3, 01.01.2000, p. 223-228.

Research output: Contribution to journalArticle

Toh, Y, Kuninaka, S, Mori, M, Oshiro, T, Ikeda, Y, Nakashima, H, Baba, H, Kohnoe, S, Okamura, T & Sugimachi, K 2000, 'Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma', Oncology, vol. 59, no. 3, pp. 223-228. https://doi.org/10.1159/000012165
Toh, Yasushi ; Kuninaka, Shinji ; Mori, Masaki ; Oshiro, Tatsuro ; Ikeda, Yasuharu ; Nakashima, Hideaki ; Baba, Hideo ; Kohnoe, Shunji ; Okamura, Takeshi ; Sugimachi, Keizo. / Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma. In: Oncology. 2000 ; Vol. 59, No. 3. pp. 223-228.
@article{8eb478b19cfa4afaae377cd6b35b9db9,
title = "Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma",
abstract = "Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the corresponding normal mucosal tissues by reverse transcription-polymerase chain reaction. The tumor/normal (T/N) ratio of 45 patients with esophageal carcinoma was calculated, and the data were clinicopathologically analyzed. The T/N ratio of Mn-SOD mRNA expression was less than 0.5 in 11 (32.4{\%}) of 34 esophageal carcinoma cases without any preoperative treatments, while none of 11 cases who underwent preoperative chemotherapy showed a T/N ratio of <0.5 (p < 0.05). There was an inverse correlation between the Mn-SOD expression level and the degree of venous invasion (p < 0.05) as well as lymphatic invasion (p < 0.05). Furthermore, poorly differentiated squamous cell carcinoma showed significantly lower Mn-SOD mRNA expression levels than well differentiated carcinoma (p < 0.05). Our results suggest that Mn-SOD mRNA was frequently reduced in esophageal carcinoma when compared to the normal mucosa and the reduced expression levels of Mn-SOD mRNA may lead to an accumulation of superoxide radicals in conjunction with the increased invasiveness of esophageal carcinoma. Copyright (C) 2000 S. Karger AG, Basel.",
author = "Yasushi Toh and Shinji Kuninaka and Masaki Mori and Tatsuro Oshiro and Yasuharu Ikeda and Hideaki Nakashima and Hideo Baba and Shunji Kohnoe and Takeshi Okamura and Keizo Sugimachi",
year = "2000",
month = "1",
day = "1",
doi = "10.1159/000012165",
language = "English",
volume = "59",
pages = "223--228",
journal = "Oncology",
issn = "0030-2414",
publisher = "S. Karger AG",
number = "3",

}

TY - JOUR

T1 - Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma

AU - Toh, Yasushi

AU - Kuninaka, Shinji

AU - Mori, Masaki

AU - Oshiro, Tatsuro

AU - Ikeda, Yasuharu

AU - Nakashima, Hideaki

AU - Baba, Hideo

AU - Kohnoe, Shunji

AU - Okamura, Takeshi

AU - Sugimachi, Keizo

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the corresponding normal mucosal tissues by reverse transcription-polymerase chain reaction. The tumor/normal (T/N) ratio of 45 patients with esophageal carcinoma was calculated, and the data were clinicopathologically analyzed. The T/N ratio of Mn-SOD mRNA expression was less than 0.5 in 11 (32.4%) of 34 esophageal carcinoma cases without any preoperative treatments, while none of 11 cases who underwent preoperative chemotherapy showed a T/N ratio of <0.5 (p < 0.05). There was an inverse correlation between the Mn-SOD expression level and the degree of venous invasion (p < 0.05) as well as lymphatic invasion (p < 0.05). Furthermore, poorly differentiated squamous cell carcinoma showed significantly lower Mn-SOD mRNA expression levels than well differentiated carcinoma (p < 0.05). Our results suggest that Mn-SOD mRNA was frequently reduced in esophageal carcinoma when compared to the normal mucosa and the reduced expression levels of Mn-SOD mRNA may lead to an accumulation of superoxide radicals in conjunction with the increased invasiveness of esophageal carcinoma. Copyright (C) 2000 S. Karger AG, Basel.

AB - Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the corresponding normal mucosal tissues by reverse transcription-polymerase chain reaction. The tumor/normal (T/N) ratio of 45 patients with esophageal carcinoma was calculated, and the data were clinicopathologically analyzed. The T/N ratio of Mn-SOD mRNA expression was less than 0.5 in 11 (32.4%) of 34 esophageal carcinoma cases without any preoperative treatments, while none of 11 cases who underwent preoperative chemotherapy showed a T/N ratio of <0.5 (p < 0.05). There was an inverse correlation between the Mn-SOD expression level and the degree of venous invasion (p < 0.05) as well as lymphatic invasion (p < 0.05). Furthermore, poorly differentiated squamous cell carcinoma showed significantly lower Mn-SOD mRNA expression levels than well differentiated carcinoma (p < 0.05). Our results suggest that Mn-SOD mRNA was frequently reduced in esophageal carcinoma when compared to the normal mucosa and the reduced expression levels of Mn-SOD mRNA may lead to an accumulation of superoxide radicals in conjunction with the increased invasiveness of esophageal carcinoma. Copyright (C) 2000 S. Karger AG, Basel.

UR - http://www.scopus.com/inward/record.url?scp=0033768576&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033768576&partnerID=8YFLogxK

U2 - 10.1159/000012165

DO - 10.1159/000012165

M3 - Article

C2 - 11053990

AN - SCOPUS:0033768576

VL - 59

SP - 223

EP - 228

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 3

ER -