Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice

K. Tano, H. Hamamoto, T. Ito, Eriko Matsumoto, R. Rakwal, J. Shibato, Y. Masuo, K. Ijiri, K. Sekimizu, N. Akimitsu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

SII-K1 is a member of the transcription elongation factor S-II family. In the mouse, SII-K1 is expressed exclusively in the liver, kidney, heart, and skeletal muscle. Here, we report that deletion of the SII-K1 gene in mice resulted in the downregulation of the synaptotagmin-like 1 (Sytl 1) gene in liver and of the coiled-coil domain-containing 21 (Ccdc21) gene in liver and kidney. Moreover, the induction of the metallothionein I (Mt I) gene in SII-K1-deficient mice liver was impaired in diethyl maleate-induced oxidative stress conditions. Our results suggest that SII-K1 regulates these genes in vivo.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalDrug discoveries & therapeutics
Volume4
Issue number5
Publication statusPublished - Oct 1 2010
Externally publishedYes

Fingerprint

Synaptotagmin I
Metallothionein
Knockout Mice
Oxidative Stress
diethyl maleate
Genes
Liver
Kidney
Myocardium
Skeletal Muscle
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice. / Tano, K.; Hamamoto, H.; Ito, T.; Matsumoto, Eriko; Rakwal, R.; Shibato, J.; Masuo, Y.; Ijiri, K.; Sekimizu, K.; Akimitsu, N.

In: Drug discoveries & therapeutics, Vol. 4, No. 5, 01.10.2010, p. 368-372.

Research output: Contribution to journalArticle

Tano, K, Hamamoto, H, Ito, T, Matsumoto, E, Rakwal, R, Shibato, J, Masuo, Y, Ijiri, K, Sekimizu, K & Akimitsu, N 2010, 'Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice', Drug discoveries & therapeutics, vol. 4, no. 5, pp. 368-372.
Tano, K. ; Hamamoto, H. ; Ito, T. ; Matsumoto, Eriko ; Rakwal, R. ; Shibato, J. ; Masuo, Y. ; Ijiri, K. ; Sekimizu, K. ; Akimitsu, N. / Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice. In: Drug discoveries & therapeutics. 2010 ; Vol. 4, No. 5. pp. 368-372.
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AU - Rakwal, R.

AU - Shibato, J.

AU - Masuo, Y.

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