Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice

K. Tano, H. Hamamoto, T. Ito, E. Sumiya, R. Rakwal, J. Shibato, Y. Masuo, K. Ijiri, K. Sekimizu, N. Akimitsu

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Abstract

SII-K1 is a member of the transcription elongation factor S-II family. In the mouse, SII-K1 is expressed exclusively in the liver, kidney, heart, and skeletal muscle. Here, we report that deletion of the SII-K1 gene in mice resulted in the downregulation of the synaptotagmin-like 1 (Sytl 1) gene in liver and of the coiled-coil domain-containing 21 (Ccdc21) gene in liver and kidney. Moreover, the induction of the metallothionein I (Mt I) gene in SII-K1-deficient mice liver was impaired in diethyl maleate-induced oxidative stress conditions. Our results suggest that SII-K1 regulates these genes in vivo.

Original languageEnglish
Pages (from-to)368-372
Number of pages5
JournalDrug discoveries & therapeutics
Volume4
Issue number5
Publication statusPublished - Oct 1 2010
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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