Abstract
A reduced ratio of plasma eicosapentaenoic acid-arachidonic acid (EPA-AA) is a newly recognized atherosclerotic risk factor. This ratio has not been fully investigated in peripheral artery disease (PAD). Seventy Japanese patients with atherosclerotic risk factors were enrolled and divided into 2 groups, those with PAD (group A: n = 38) and those without PAD (group B: n = 32). The EPA-AA ratio (P =.001) and ankle-brachial index (ABI: P <.001) in group A were significantly lower than those in group B. Univariate and multivariate analyses demonstrated that EPA-AA, ABI, and prescription of clopidogrel had significant correlation with PAD. Given the appropriate cutoff values, EPA-AA (odds ratio [OR] = 11.7, 95% confidence interval [CI] = 3.0-45.8; P <.001) and ABI (OR = 44.0, 95% CI = 5.4-358.5; P <.001) are factors independently associated with PAD. In conclusion, this study demonstrated that reduced plasma EPA/AA may underlie PAD at least in Japanese.
| Original language | English |
|---|---|
| Pages (from-to) | 112-118 |
| Number of pages | 7 |
| Journal | Angiology |
| Volume | 64 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 2013 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
Cite this
Reduced plasma eicosapentaenoic acid-arachidonic acid ratio in peripheral artery disease. / Fujihara, Masahiko; Fukata, Mitsuhiro; Odashiro, Keita; Maruyama, Toru; Akashi, Koichi; Yokoi, Yoshiaki.
In: Angiology, Vol. 64, No. 2, 01.01.2013, p. 112-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced plasma eicosapentaenoic acid-arachidonic acid ratio in peripheral artery disease
AU - Fujihara, Masahiko
AU - Fukata, Mitsuhiro
AU - Odashiro, Keita
AU - Maruyama, Toru
AU - Akashi, Koichi
AU - Yokoi, Yoshiaki
PY - 2013/1/1
Y1 - 2013/1/1
N2 - A reduced ratio of plasma eicosapentaenoic acid-arachidonic acid (EPA-AA) is a newly recognized atherosclerotic risk factor. This ratio has not been fully investigated in peripheral artery disease (PAD). Seventy Japanese patients with atherosclerotic risk factors were enrolled and divided into 2 groups, those with PAD (group A: n = 38) and those without PAD (group B: n = 32). The EPA-AA ratio (P =.001) and ankle-brachial index (ABI: P <.001) in group A were significantly lower than those in group B. Univariate and multivariate analyses demonstrated that EPA-AA, ABI, and prescription of clopidogrel had significant correlation with PAD. Given the appropriate cutoff values, EPA-AA (odds ratio [OR] = 11.7, 95% confidence interval [CI] = 3.0-45.8; P <.001) and ABI (OR = 44.0, 95% CI = 5.4-358.5; P <.001) are factors independently associated with PAD. In conclusion, this study demonstrated that reduced plasma EPA/AA may underlie PAD at least in Japanese.
AB - A reduced ratio of plasma eicosapentaenoic acid-arachidonic acid (EPA-AA) is a newly recognized atherosclerotic risk factor. This ratio has not been fully investigated in peripheral artery disease (PAD). Seventy Japanese patients with atherosclerotic risk factors were enrolled and divided into 2 groups, those with PAD (group A: n = 38) and those without PAD (group B: n = 32). The EPA-AA ratio (P =.001) and ankle-brachial index (ABI: P <.001) in group A were significantly lower than those in group B. Univariate and multivariate analyses demonstrated that EPA-AA, ABI, and prescription of clopidogrel had significant correlation with PAD. Given the appropriate cutoff values, EPA-AA (odds ratio [OR] = 11.7, 95% confidence interval [CI] = 3.0-45.8; P <.001) and ABI (OR = 44.0, 95% CI = 5.4-358.5; P <.001) are factors independently associated with PAD. In conclusion, this study demonstrated that reduced plasma EPA/AA may underlie PAD at least in Japanese.
UR - http://www.scopus.com/inward/record.url?scp=84872582809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872582809&partnerID=8YFLogxK
U2 - 10.1177/0003319712437031
DO - 10.1177/0003319712437031
M3 - Article
C2 - 22371626
AN - SCOPUS:84872582809
VL - 64
SP - 112
EP - 118
JO - Angiology
JF - Angiology
SN - 0003-3197
IS - 2
ER -