Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver

Shinya Iida, Hiroyuki Kamiya, Akihiro Nakaya, Yasuhiro Hayashi, Akihiro Sawada, Noritada Kaji, Yoshinobu Baba, Hideyoshi Harashima

Research output: Contribution to journalArticle

Abstract

Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.

Original languageEnglish
Pages (from-to)2009-2011
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume36
Issue number12
DOIs
Publication statusPublished - Dec 2013

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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    Iida, S., Kamiya, H., Nakaya, A., Hayashi, Y., Sawada, A., Kaji, N., Baba, Y., & Harashima, H. (2013). Reduced plasma glucose by asparagine synthetase knockdown in the mouse liver. Biological and Pharmaceutical Bulletin, 36(12), 2009-2011. https://doi.org/10.1248/bpb.b13-00414