Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin

Hoyoku Nishino, Hirota Fujiki, Masami Suganuma, Takahiko Horiuchi, Akio Iwashima, Takashi Sugimura

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Abstract

A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 μmoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-0-tetradecanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.

Original languageEnglish
Pages (from-to)726-730
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume124
Issue number3
DOIs
Publication statusPublished - Nov 14 1984
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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