A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 μmoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-0-tetradecanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Nov 14 1984|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology