Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin

Hoyoku Nishino, Hirota Fujiki, Masami Suganuma, Takahiko Horiuchi, Akio Iwashima, Takashi Sugimura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 μmoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-0-tetradecanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.

Original languageEnglish
Pages (from-to)726-730
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume124
Issue number3
DOIs
Publication statusPublished - Nov 14 1984
Externally publishedYes

Fingerprint

Calmodulin
Skin
Tetradecanoylphorbol Acetate
Acetates
W 7
phorbol ester receptor

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin. / Nishino, Hoyoku; Fujiki, Hirota; Suganuma, Masami; Horiuchi, Takahiko; Iwashima, Akio; Sugimura, Takashi.

In: Biochemical and Biophysical Research Communications, Vol. 124, No. 3, 14.11.1984, p. 726-730.

Research output: Contribution to journalArticle

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