TY - JOUR
T1 - Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin
AU - Nishino, Hoyoku
AU - Fujiki, Hirota
AU - Suganuma, Masami
AU - Horiuchi, Takahiko
AU - Iwashima, Akio
AU - Sugimura, Takashi
PY - 1984/11/14
Y1 - 1984/11/14
N2 - A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 μmoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-0-tetradecanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.
AB - A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), reduced the number of phorbol ester receptors in mouse skin in a dose- and time-dependent manner. The reduction occurred immediately after topical application of 30 μmoles of W-7, reaching a maximum of 86% after 5 min. Reduction in specific binding of 12-0-tetradecanoylphorbol-13-acetate can explain the antitumor promoting activity of W-7 in mouse skin.
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U2 - 10.1016/0006-291X(84)91018-0
DO - 10.1016/0006-291X(84)91018-0
M3 - Article
C2 - 6508780
AN - SCOPUS:0021715918
SN - 0006-291X
VL - 124
SP - 726
EP - 730
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -