Reduction of antides to amines via catalytic hydrosilylation by a rhodium complex

Ryoichi Kuwano, Masatoshi Takahashi, Yoshihiko Ito

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Reduction of a wide range of tertiary amides with 2 molar equivalents of diphenylsilane was promoted by 0.1 mol% of RhH(CO)(PPh3)3 at room temperature, affording the corresponding tertiary amines in high yields. The synthetic utility is demonstrated by chemoselective reductions of amides having functional groups such as ester and epoxy groups which are not tolerated by the conventional reductions with LiAlH4 and BH3.

Original languageEnglish
Pages (from-to)1017-1020
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number9
DOIs
Publication statusPublished - Feb 26 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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