Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension

Hongyu Piao, Akihiko Hirata, Hideakira Yokoyama, Takeru Fujii, Ichiro Shimizu, Susumu Ito, Noriho Kamiya, Masahiro Goto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This article reports a significant reduction of gastric ulcerogenicity by complex formation of a nonsteroidal anti-inflammatory drug with surfactants. Diclofenac sodium (DFNa) was suspended in medium chain triglyceride (MCT) by forming a complex with an edible lipophilic surfactant. Two types of suspensions, prepared through a membrane emulsification with different pore sizes, were evaluated according to the degree of gastric damage following multiple oral administration in rats. It was shown that gastric ulcerogenicity of DFNa was reduced by the surfactant-drug complexes, at doses up to 12 mg/kg, whereas severe gastric damage was observed upon oral administration of the aqueous solution at doses of 6 mg/kg. Comparable blood levels of DFNa were observed after administration of solution and suspension formulations.

Original languageEnglish
Pages (from-to)321-325
Number of pages5
JournalPharmaceutical Development and Technology
Volume12
Issue number3
DOIs
Publication statusPublished - May 1 2007

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Diclofenac
Stomach
Suspensions
Oils
Surface-Active Agents
Oral Administration
Pharmaceutical Preparations
Triglycerides
Anti-Inflammatory Agents
Membranes

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension. / Piao, Hongyu; Hirata, Akihiko; Yokoyama, Hideakira; Fujii, Takeru; Shimizu, Ichiro; Ito, Susumu; Kamiya, Noriho; Goto, Masahiro.

In: Pharmaceutical Development and Technology, Vol. 12, No. 3, 01.05.2007, p. 321-325.

Research output: Contribution to journalArticle

Piao, Hongyu ; Hirata, Akihiko ; Yokoyama, Hideakira ; Fujii, Takeru ; Shimizu, Ichiro ; Ito, Susumu ; Kamiya, Noriho ; Goto, Masahiro. / Reduction of gastric ulcerogenicity during multiple administration of diclofenac sodium by a novel solid-in-oil suspension. In: Pharmaceutical Development and Technology. 2007 ; Vol. 12, No. 3. pp. 321-325.
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