Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation

A. Tsukamoto; H. Kuma; K. Saitoh; A. Kandori; K. Yoshinaga; Y. Sugiura; N. Hamasaki; K. Enpuku

doi:10.1016/j.physc.2007.04.284

Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation

A. Tsukamoto, H. Kuma, K. Saitoh, A. Kandori, K. Yoshinaga, Y. Sugiura, N. Hamasaki, K. Enpuku

Superconductive Systems Engineering Laboratory

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We investigated the effect of adding magnetic shielding and applying of a compensation field to reduce the magnetic signal from unbound free markers. When the initial immunoassay system was used without the additional shielding box, the signal intensity of the liquid markers normalized by the weight of the Fe₃O₄ was 1/2700 of the dried markers. By installing the additional shielding box, the reduction factor was improved to 1/10,000. We successfully reduced the magnetic signal of the liquid marker further by applying a compensation field. The magnetic signal of the free marker obtained by applying a compensation field of -18 nT was 1.4 mΦ₀, which was close to the system noise level. Field compensation at the very local area just around the SQUID is sufficient for reducing of the magnetic signal from the free marker.

Original language	English
Pages (from-to)	1024-1028
Number of pages	5
Journal	Physica C: Superconductivity and its applications
Volume	463-465
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/j.physc.2007.04.284
Publication status	Published - Oct 1 2007

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Energy Engineering and Power Technology
Electrical and Electronic Engineering

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10.1016/j.physc.2007.04.284

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Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation. / Tsukamoto, A.; Kuma, H.; Saitoh, K.; Kandori, A.; Yoshinaga, K.; Sugiura, Y.; Hamasaki, N.; Enpuku, K.

In: Physica C: Superconductivity and its applications, Vol. 463-465, No. SUPPL., 01.10.2007, p. 1024-1028.

Research output: Contribution to journal › Article › peer-review

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AU - Tsukamoto, A.

AU - Kuma, H.

AU - Saitoh, K.

AU - Kandori, A.

AU - Yoshinaga, K.

AU - Sugiura, Y.

AU - Hamasaki, N.

AU - Enpuku, K.

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