Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation

A. Tsukamoto, H. Kuma, K. Saitoh, A. Kandori, K. Yoshinaga, Y. Sugiura, N. Hamasaki, Keiji Enpuku

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We investigated the effect of adding magnetic shielding and applying of a compensation field to reduce the magnetic signal from unbound free markers. When the initial immunoassay system was used without the additional shielding box, the signal intensity of the liquid markers normalized by the weight of the Fe3O4 was 1/2700 of the dried markers. By installing the additional shielding box, the reduction factor was improved to 1/10,000. We successfully reduced the magnetic signal of the liquid marker further by applying a compensation field. The magnetic signal of the free marker obtained by applying a compensation field of -18 nT was 1.4 mΦ0, which was close to the system noise level. Field compensation at the very local area just around the SQUID is sufficient for reducing of the magnetic signal from the free marker.

Original languageEnglish
Pages (from-to)1024-1028
Number of pages5
JournalPhysica C: Superconductivity and its applications
Volume463-465
Issue numberSUPPL.
DOIs
Publication statusPublished - Oct 1 2007

Fingerprint

magnetic signals
immunoassay
markers
Shielding
Magnetic shielding
shielding
boxes
SQUIDs
Liquids
magnetic shielding
liquids
installing
Compensation and Redress

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering

Cite this

Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation. / Tsukamoto, A.; Kuma, H.; Saitoh, K.; Kandori, A.; Yoshinaga, K.; Sugiura, Y.; Hamasaki, N.; Enpuku, Keiji.

In: Physica C: Superconductivity and its applications, Vol. 463-465, No. SUPPL., 01.10.2007, p. 1024-1028.

Research output: Contribution to journalArticle

Tsukamoto, A, Kuma, H, Saitoh, K, Kandori, A, Yoshinaga, K, Sugiura, Y, Hamasaki, N & Enpuku, K 2007, 'Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation', Physica C: Superconductivity and its applications, vol. 463-465, no. SUPPL., pp. 1024-1028. https://doi.org/10.1016/j.physc.2007.04.284
Tsukamoto, A. ; Kuma, H. ; Saitoh, K. ; Kandori, A. ; Yoshinaga, K. ; Sugiura, Y. ; Hamasaki, N. ; Enpuku, Keiji. / Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation. In: Physica C: Superconductivity and its applications. 2007 ; Vol. 463-465, No. SUPPL. pp. 1024-1028.
@article{fab86a9fea3945dda32103efe9168c2b,
title = "Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation",
abstract = "We investigated the effect of adding magnetic shielding and applying of a compensation field to reduce the magnetic signal from unbound free markers. When the initial immunoassay system was used without the additional shielding box, the signal intensity of the liquid markers normalized by the weight of the Fe3O4 was 1/2700 of the dried markers. By installing the additional shielding box, the reduction factor was improved to 1/10,000. We successfully reduced the magnetic signal of the liquid marker further by applying a compensation field. The magnetic signal of the free marker obtained by applying a compensation field of -18 nT was 1.4 mΦ0, which was close to the system noise level. Field compensation at the very local area just around the SQUID is sufficient for reducing of the magnetic signal from the free marker.",
author = "A. Tsukamoto and H. Kuma and K. Saitoh and A. Kandori and K. Yoshinaga and Y. Sugiura and N. Hamasaki and Keiji Enpuku",
year = "2007",
month = "10",
day = "1",
doi = "10.1016/j.physc.2007.04.284",
language = "English",
volume = "463-465",
pages = "1024--1028",
journal = "Physica C: Superconductivity and its Applications",
issn = "0921-4534",
publisher = "Elsevier",
number = "SUPPL.",

}

TY - JOUR

T1 - Reduction of the magnetic signal from unbound magnetic markers for magnetic immunoassay without bound/free separation

AU - Tsukamoto, A.

AU - Kuma, H.

AU - Saitoh, K.

AU - Kandori, A.

AU - Yoshinaga, K.

AU - Sugiura, Y.

AU - Hamasaki, N.

AU - Enpuku, Keiji

PY - 2007/10/1

Y1 - 2007/10/1

N2 - We investigated the effect of adding magnetic shielding and applying of a compensation field to reduce the magnetic signal from unbound free markers. When the initial immunoassay system was used without the additional shielding box, the signal intensity of the liquid markers normalized by the weight of the Fe3O4 was 1/2700 of the dried markers. By installing the additional shielding box, the reduction factor was improved to 1/10,000. We successfully reduced the magnetic signal of the liquid marker further by applying a compensation field. The magnetic signal of the free marker obtained by applying a compensation field of -18 nT was 1.4 mΦ0, which was close to the system noise level. Field compensation at the very local area just around the SQUID is sufficient for reducing of the magnetic signal from the free marker.

AB - We investigated the effect of adding magnetic shielding and applying of a compensation field to reduce the magnetic signal from unbound free markers. When the initial immunoassay system was used without the additional shielding box, the signal intensity of the liquid markers normalized by the weight of the Fe3O4 was 1/2700 of the dried markers. By installing the additional shielding box, the reduction factor was improved to 1/10,000. We successfully reduced the magnetic signal of the liquid marker further by applying a compensation field. The magnetic signal of the free marker obtained by applying a compensation field of -18 nT was 1.4 mΦ0, which was close to the system noise level. Field compensation at the very local area just around the SQUID is sufficient for reducing of the magnetic signal from the free marker.

UR - http://www.scopus.com/inward/record.url?scp=34548495354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548495354&partnerID=8YFLogxK

U2 - 10.1016/j.physc.2007.04.284

DO - 10.1016/j.physc.2007.04.284

M3 - Article

AN - SCOPUS:34548495354

VL - 463-465

SP - 1024

EP - 1028

JO - Physica C: Superconductivity and its Applications

JF - Physica C: Superconductivity and its Applications

SN - 0921-4534

IS - SUPPL.

ER -