TY - JOUR
T1 - Refined glioma classification based on molecular pathology
AU - Mizoguchi, Masahiro
N1 - Publisher Copyright:
© 2015, Japanese Congress of Neurological Surgeons. All rights reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2015
Y1 - 2015
N2 - The Cancer Genome Atlas (TCGA), which is a multidimensional and comprehensive analyses of genomic/epigenomic alterations, has identified novel molecular changes on multiple regulatory levels (genomic, transcriptional, epigenomic) in human gliomas. The development of new technologies, such as next generation sequencing, has accelerated systematic studies of the cancer genome in recent years. Accordingly, our understanding has rapidly expanded, and some of the newly discovered molecular alterations are critical for the application of personalized medicine. These kinds of analyses have, however, also revealed the complexity of the glioma molecular basis. In this review, we will summarize these novel genetic/epigenetic insights into the nature of glioma, and further discuss its genomic complexity.
AB - The Cancer Genome Atlas (TCGA), which is a multidimensional and comprehensive analyses of genomic/epigenomic alterations, has identified novel molecular changes on multiple regulatory levels (genomic, transcriptional, epigenomic) in human gliomas. The development of new technologies, such as next generation sequencing, has accelerated systematic studies of the cancer genome in recent years. Accordingly, our understanding has rapidly expanded, and some of the newly discovered molecular alterations are critical for the application of personalized medicine. These kinds of analyses have, however, also revealed the complexity of the glioma molecular basis. In this review, we will summarize these novel genetic/epigenetic insights into the nature of glioma, and further discuss its genomic complexity.
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U2 - 10.7887/jcns.24.366
DO - 10.7887/jcns.24.366
M3 - Article
AN - SCOPUS:84933040018
VL - 24
SP - 366
EP - 377
JO - Japanese Journal of Neurosurgery
JF - Japanese Journal of Neurosurgery
SN - 0917-950X
IS - 6
ER -