Refractive error is associated with intracranial volume

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Yuki Yamamoto, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Takamitsu Shinada, Kohei Sakaki, Yuko Sassa, Takayuki Nozawa, Shigeyuki Ikeda, Susumu Yokota, Magistro Daniele, Ryuta Kawashima

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Myopia is part of the spectrum of refractive error. Myopia is associated with psychometric intelligence and, the link between brain anatomy and myopia has been hypothesized. Here we aimed to identify the associations between brain structures and refractive error in developed young adults. In a study cohort of 1,319 normal educated young adults, the refractive error showed a significant negative correlation with total intracranial volume and total cerebrospinal fluid (CSF) volume but not with total gray matter volume (GMV) or total white matter volume (WMV). Time spent studying was associated with refractive error but could not explain the aforementioned associations with brain volume parameters. The R 2 values of the simple regression between spherical equivalent and outcome variables for each sex in non-whole brain imaging analyses were less than 0.05 in all cases and thus were weak. Psychometric intelligence was not associated with refractive error or total CSF volume, but it weakly positively correlated with total GMV and total WMV in this study population. Thus, refractive error appears to be primarily (weakly) associated with the volume of the cranium, whereas psychometric intelligence was associated with the volume of the brain.

Original languageEnglish
Article number175
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

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Refractive Errors
Myopia
Intelligence
Psychometrics
Brain
Cerebrospinal Fluid
Young Adult
Skull
Neuroimaging
Anatomy
Cohort Studies
Population

All Science Journal Classification (ASJC) codes

  • General

Cite this

Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., ... Kawashima, R. (2018). Refractive error is associated with intracranial volume. Scientific reports, 8(1), [175]. https://doi.org/10.1038/s41598-017-18669-0

Refractive error is associated with intracranial volume. / Takeuchi, Hikaru; Taki, Yasuyuki; Nouchi, Rui; Yokoyama, Ryoichi; Kotozaki, Yuka; Nakagawa, Seishu; Sekiguchi, Atsushi; Iizuka, Kunio; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Miyauchi, Carlos Makoto; Shinada, Takamitsu; Sakaki, Kohei; Sassa, Yuko; Nozawa, Takayuki; Ikeda, Shigeyuki; Yokota, Susumu; Daniele, Magistro; Kawashima, Ryuta.

In: Scientific reports, Vol. 8, No. 1, 175, 01.12.2018.

Research output: Contribution to journalArticle

Takeuchi, H, Taki, Y, Nouchi, R, Yokoyama, R, Kotozaki, Y, Nakagawa, S, Sekiguchi, A, Iizuka, K, Yamamoto, Y, Hanawa, S, Araki, T, Miyauchi, CM, Shinada, T, Sakaki, K, Sassa, Y, Nozawa, T, Ikeda, S, Yokota, S, Daniele, M & Kawashima, R 2018, 'Refractive error is associated with intracranial volume', Scientific reports, vol. 8, no. 1, 175. https://doi.org/10.1038/s41598-017-18669-0
Takeuchi H, Taki Y, Nouchi R, Yokoyama R, Kotozaki Y, Nakagawa S et al. Refractive error is associated with intracranial volume. Scientific reports. 2018 Dec 1;8(1). 175. https://doi.org/10.1038/s41598-017-18669-0
Takeuchi, Hikaru ; Taki, Yasuyuki ; Nouchi, Rui ; Yokoyama, Ryoichi ; Kotozaki, Yuka ; Nakagawa, Seishu ; Sekiguchi, Atsushi ; Iizuka, Kunio ; Yamamoto, Yuki ; Hanawa, Sugiko ; Araki, Tsuyoshi ; Miyauchi, Carlos Makoto ; Shinada, Takamitsu ; Sakaki, Kohei ; Sassa, Yuko ; Nozawa, Takayuki ; Ikeda, Shigeyuki ; Yokota, Susumu ; Daniele, Magistro ; Kawashima, Ryuta. / Refractive error is associated with intracranial volume. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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