Regio- and stereocontrolled introduction of secondary alkyl groups to electron-deficient arenes through copper-catalyzed allylic alkylation

Copper-catalyzed allylic alkylation of azoles, a pyridine N-oxide, and fluoroarenes with secondary allylic phosphates proceeded under mild reaction conditions with excellent γ-E-selectivity. The reactions with enantioenriched allylic phosphates proceeded with 1,3-anti stereoselectivity to generate an allylic stereogenic center at the position α to the aromatic ring.