Regio- and stereocontrolled introduction of secondary alkyl groups to electron-deficient arenes through copper-catalyzed allylic alkylation

Yusuke Makida, Hirohisa Ohmiya, Masaya Sawamura

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

Copper-catalyzed allylic alkylation of azoles, a pyridine N-oxide, and fluoroarenes with secondary allylic phosphates proceeded under mild reaction conditions with excellent γ-E-selectivity. The reactions with enantioenriched allylic phosphates proceeded with 1,3-anti stereoselectivity to generate an allylic stereogenic center at the position α to the aromatic ring.

Original languageEnglish
Pages (from-to)4122-4127
Number of pages6
JournalAngewandte Chemie - International Edition
Volume51
Issue number17
DOIs
Publication statusPublished - Apr 23 2012

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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