Region-specific changes in [3H]dizocilpine binding in diazepam- withdrawn rats

Makoto Tsuda, Tsutomu Suzuki, Miwa Misawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In the present study, to clarify the role of the N-methyl-D-aspartate (NMDA) receptor in the appearance of diazepam withdrawal signs, the changes in [3H]dizocilpine binding in several brain regions from diazepam-withdrawn rats were investigated. Brain membranes were prepared 42-45 h after termination of diazepam treatment when maximal withdrawal signs were shown. The B(max) value for [3H]dizocilpine binding was significantly increased in cerebrocortical, but not hippocampal and cerebellar, tissues from diazepam- withdrawn rats, while the K(d) value did not change in any group. Together with our previous finding that NMDA receptor antagonists potently suppress diazepam withdrawal signs, these results suggest that the upregulation of the NMDA receptor in the cerebral cortex may play an important role in the appearance of spontaneous withdrawal signs caused by discontinuation of chronic diazepam treatment.

Original languageEnglish
Pages (from-to)113-115
Number of pages3
JournalNeuroscience Letters
Volume240
Issue number2
DOIs
Publication statusPublished - Jan 9 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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