Regional differences in the pattern of neurogenic responses in the aganglionic colon from congenitally aganglionic rats

Masayuki Kubota, Yushi Ito, Tomoaki Taguchi, Keiichi Ikeda, Hiroshi Ikadai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The pattern of innervation in the aganglionic colon and internal anal sphincter from cogenitally aganglionic rats was studied and compared with that of control littermates. In normoganglionic colon and anal sphincter, electrical stimulation evoked excitatory or inhibitory junction potentials followed by a contraction or relaxation, respectively. These responses were abolished by tetrodotoxin and atropine selectively abolished the excitatory effects, indicating that the colon or anal sphincter is innervated by intrinsic cholinergic excitatory and noncholinergic inhibitory nerves. In congenitally aganglionic rats, electrical stimulation evoked excitatory and inhibitory responses in sphincteric regions, while only excitatory responses were observed in distal segments. Excitatory responses were weak in proximal segments of the aganglionic colon and electrical stimulation failed to evoke neurogenic responses. These results indicate regional differences in the functional innervation of extrinsic nerve fibers in the aganglionic colon from congenitally aganglionic rats and the usefulness of congenitally aganglionic rats as an animal model for Hirschsprung's disease.

Original languageEnglish
Pages (from-to)911-919
Number of pages9
JournalJournal of Pediatric Surgery
Volume24
Issue number9
DOIs
Publication statusPublished - Sep 1989

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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