We report new methods for the synthesis of intramolecularly-bridged calixarenes by bis(bromomethyl)reagents. We could isolate not only singly-bridged compounds but also a doubly-bridged compound. The doubly-bridged compound has a unique capsule-like structure, the cavity of which consists of eight phenolic oxygens.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry