TY - JOUR
T1 - Regioselective ring-opening reaction of 2-trifluoromethyl-N-tosylaziridine with some nucleophiles under basic conditions
AU - Takehiro, Yui
AU - Hirotaki, Kensuke
AU - Takeshita, Chihomi
AU - Furuno, Hiroshi
AU - Hanamoto, Takeshi
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/9/2
Y1 - 2013/9/2
N2 - The ring-opening reaction of 2-trifluoromethyl-N-tosylaziridine with a variety of heteroatom- and carbon-centered nucleophiles was achieved under basic conditions in good to high yield with excellent regioselectivity. These findings enabled an easy access to useful α-trifluoromethyl-N- tosylmethylamine derivatives, such as 1,2-aminoalcohol, 1,2-diamine, 1,2-aminothiol, and distant secondary amine.
AB - The ring-opening reaction of 2-trifluoromethyl-N-tosylaziridine with a variety of heteroatom- and carbon-centered nucleophiles was achieved under basic conditions in good to high yield with excellent regioselectivity. These findings enabled an easy access to useful α-trifluoromethyl-N- tosylmethylamine derivatives, such as 1,2-aminoalcohol, 1,2-diamine, 1,2-aminothiol, and distant secondary amine.
UR - http://www.scopus.com/inward/record.url?scp=84880707694&partnerID=8YFLogxK
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U2 - 10.1016/j.tet.2013.06.044
DO - 10.1016/j.tet.2013.06.044
M3 - Article
AN - SCOPUS:84880707694
VL - 69
SP - 7448
EP - 7454
JO - Tetrahedron
JF - Tetrahedron
SN - 0040-4020
IS - 35
ER -