Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in Mammals

Naotada Ishihara, Hidenori Otera, Toshihiko Oka, Katsuyoshi Mihara

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Significance: Mitochondria are double membrane-bound organelles with tubular network structures that are essential for oxidative ATP production and play pivotal roles in regulating calcium homeostasis and apoptosis. Furthermore, mitochondria produce large amounts of reactive oxygen species that are fatal to cellular functions through uncoupled respiration. These organelles dynamically change their morphology by frequent fusion and fission, and three types of high molecular weight GTPase proteins have been identified as core components of the fusion and fission machineries. Recent Advances: Here, we review recent advances in the study of mitochondrial fission and fusion GTPases and their physiologic roles in mammalian cells. The regulation of mitochondrial dynamics coupled with a quality control system is essential for cellular homeostasis, development, and tissue differentiation. Defects of these mechanisms cause various disorders, including neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease. Critical Issues: Although a significant amount of relevant data has accumulated on the regulation of mammalian mitochondrial fusion and fission, mechanistic molecular details and cellular functions still remain insufficiently defined. Future Directions: Elucidating the physiologic roles of mitochondrial fusion and fission in highly differentiated cells using tissue-specific knockout mice remains a challenge for the future. Antioxid. Redox Signal. 19, 389-399.

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalAntioxidants and Redox Signaling
Volume19
Issue number4
DOIs
Publication statusPublished - Aug 1 2013

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Mitochondrial Dynamics
Mammals
GTP Phosphohydrolases
Fusion reactions
Mitochondria
Organelles
Homeostasis
Huntington Disease
Neurodegenerative diseases
Tissue
Knockout Mice
Neurodegenerative Diseases
Quality Control
Oxidation-Reduction
Parkinson Disease
Reactive Oxygen Species
Alzheimer Disease
Respiration
Adenosine Triphosphate
Molecular Weight

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in Mammals. / Ishihara, Naotada; Otera, Hidenori; Oka, Toshihiko; Mihara, Katsuyoshi.

In: Antioxidants and Redox Signaling, Vol. 19, No. 4, 01.08.2013, p. 389-399.

Research output: Contribution to journalReview article

Ishihara, Naotada ; Otera, Hidenori ; Oka, Toshihiko ; Mihara, Katsuyoshi. / Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in Mammals. In: Antioxidants and Redox Signaling. 2013 ; Vol. 19, No. 4. pp. 389-399.
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