Regulation of angiogenesis by growth factors

M. Kuwano, S. Ushiro, M. Ryuto, K. Samoto, H. Izumi, K. I. Ito, T. Abe, T. Nakamura, M. Ono, K. Kohno

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Abstract

Normal angiogenesis is self-limiting and strictly regulated while tumor angiogenesis appears to be deregulated. Angiogenesis proceeds upon a balance of angiogenic factors and inhibitors, with which expression of plasminogen activator (PA) and its inhibitor is closely associated. Angiogenic factors such as fibroblast growth factors, epidermal growth factor/transforming growth factor (TGF)-α, and vascular endothelial growth factor induce cell migration, tubulogenesis, and PA. By contrast) anti-angiogenic factors such as TGF-β and tumor necrosis factor-α inhibit cell migration tubulogenesis and expression of PA. In this article, we discuss how such angiogenic factors and anti-angiogenic factors modulate angiogenesis in model systems.

Original languageEnglish
Pages (from-to)113-125
Number of pages13
JournalGann Monographs on Cancer Research
Volume42
Publication statusPublished - Jan 1 1994

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All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Kuwano, M., Ushiro, S., Ryuto, M., Samoto, K., Izumi, H., Ito, K. I., ... Kohno, K. (1994). Regulation of angiogenesis by growth factors. Gann Monographs on Cancer Research, 42, 113-125.