Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB

Motohiro Nishida, Naoyuki Kitajima, Shota Saiki, Michio Nakaya, Hitoshi Kurose

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Angiotensin II (Ang II) is a major vasoactive peptide of the renin-angiotensin system. Ang II is originally found as one of potent vasoconstrictors, but is now attracted attention as an essential mediator of many cardiovascular problems, including endothelial dysfunction, arrhythmia and structural remodeling of cardiovascular systems. Most of the known pathophysiological effects of Ang II are mediated through Ang type1 receptors (AT 1Rs), and the up-regulation of AT 1Rs is one of important causes by which Ang II can contribute to cardiovascular diseases. A growing body of evidence has suggested that reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in the regulation of AT 1R signaling. In cardiac fibroblasts, stimulation with cytokines or bacterial toxins induces AT 1R up-regulation through NADPH oxidase-dependent ROS production. In contrast, nitric oxide (NO) decreases AT 1R density through cysteine modification (S-nitrosylation) of a transcriptional factor, nuclear factor κB (NF-κB). The difference between the effects of ROS and NO on AT 1R expression may be caused by the difference between intracellular location of ROS signaling and that of NO signaling, as the agonist-induced S-nitrosylation of NF-κB requires a local interaction between NO synthase (NOS) and NF-κB in the perinuclear region. Thus, the spatial and temporal regulation of cysteine modification by ROS or RNS may underlie the resultant changes of AT 1R signaling induced by agonist stimulation.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalNitric Oxide - Biology and Chemistry
Volume25
Issue number2
DOIs
Publication statusPublished - Aug 1 2011

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research

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