Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells

Atsushi Yasukochi, Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Mai Hazekawa, Takuya Nishinakagawa, Kazuhiko Ono, Manabu Nakashima, Seiji Nakamura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Collagen type XVII (COL17) is expressed in various tissues and its aberrant expression is associated with tumour progression. In this study, we investigated the regulation of COL17 expression in oral squamous cell carcinoma (OSCC) using the cell lines NA, SAS, Ca9-22, and Sa3. COL17 was induced upon p53 activation by cisplatin in SAS; however, this effect was more limited in NA and hardly in Ca9-22 and Sa3, with mutated p53. Moreover, COL17 was found to be regulated by miR203a-3p in all cell lines. Our data suggest that COL17 expression in OSCC cell lines is regulated by p53 and miR203a-3p.

Original languageEnglish
Pages (from-to)163-173
Number of pages11
JournalJournal of biochemistry
Volume166
Issue number2
DOIs
Publication statusPublished - Aug 1 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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