Regulation of coronary artery tone in relation to the activation of signal transductors that regulate calcium homeostasis

Toshiyuki Sasaguri, Takeo Itoh, Masato Hirata, Kenji Kitamura, Hirosi Kuriyama

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Muscle tone of coronary arteries is regulated by free calcium concentration in the myoplasm. Various agonists, autacoids and putative peptides modify the calcium concentration directly or through actions of second messengers (signal transductors), such as cyclic guanosine monophosphate (GMP), cyclic adenosine monophosphate (AMP), inositol 1,4,5-trisphosphate, diacylgly-cerol or calmodulin. For example, acetylcholine (in the presence of intact endothelium cells), alpha-human natriuretic peptide or nitrate compounds increase the amount of cyclic GMP and isoproterenol, prostacyclin (prostaglandin I 2 ) or vasoactive intestinal polypeptide increases cyclic AMP. Both cyclic nucleotides reduce free calcium concentration. On the other hand, acetylcholine (in the presence or absence of endothelium cells), norepinephrine or thromboxane A2 increases inositol 1,4,5-tris-phosphate and diacylglycerol, thus causing the increase in the free calcium concentration, whereas vasoactive intestinal peptide and alpha-human natriuretic peptide reduce them. Calmodulin acts as an internal calcium receptor for regulation of the contractile machinary. Regulation of calcium homeostasis in relation to the muscle tone in the coronary arteries including other vascular tissues is discussed together with the role of second messengers.

Original languageEnglish
Pages (from-to)1167-1175
Number of pages9
JournalJournal of the American College of Cardiology
Volume9
Issue number5
DOIs
Publication statusPublished - Jan 1 1987

Fingerprint

Coronary Vessels
Homeostasis
Calcium
Natriuretic Peptides
Vasoactive Intestinal Peptide
Second Messenger Systems
Epoprostenol
Calmodulin
Acetylcholine
Endothelium
Autacoids
Calcium-Sensing Receptors
Muscles
Thromboxane A2
Inositol 1,4,5-Trisphosphate
Cyclic Nucleotides
Diglycerides
Cyclic GMP
Inositol
Isoproterenol

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Regulation of coronary artery tone in relation to the activation of signal transductors that regulate calcium homeostasis. / Sasaguri, Toshiyuki; Itoh, Takeo; Hirata, Masato; Kitamura, Kenji; Kuriyama, Hirosi.

In: Journal of the American College of Cardiology, Vol. 9, No. 5, 01.01.1987, p. 1167-1175.

Research output: Contribution to journalArticle

@article{dbc9b196ce16477db7d06a068c646e0a,
title = "Regulation of coronary artery tone in relation to the activation of signal transductors that regulate calcium homeostasis",
abstract = "Muscle tone of coronary arteries is regulated by free calcium concentration in the myoplasm. Various agonists, autacoids and putative peptides modify the calcium concentration directly or through actions of second messengers (signal transductors), such as cyclic guanosine monophosphate (GMP), cyclic adenosine monophosphate (AMP), inositol 1,4,5-trisphosphate, diacylgly-cerol or calmodulin. For example, acetylcholine (in the presence of intact endothelium cells), alpha-human natriuretic peptide or nitrate compounds increase the amount of cyclic GMP and isoproterenol, prostacyclin (prostaglandin I 2 ) or vasoactive intestinal polypeptide increases cyclic AMP. Both cyclic nucleotides reduce free calcium concentration. On the other hand, acetylcholine (in the presence or absence of endothelium cells), norepinephrine or thromboxane A2 increases inositol 1,4,5-tris-phosphate and diacylglycerol, thus causing the increase in the free calcium concentration, whereas vasoactive intestinal peptide and alpha-human natriuretic peptide reduce them. Calmodulin acts as an internal calcium receptor for regulation of the contractile machinary. Regulation of calcium homeostasis in relation to the muscle tone in the coronary arteries including other vascular tissues is discussed together with the role of second messengers.",
author = "Toshiyuki Sasaguri and Takeo Itoh and Masato Hirata and Kenji Kitamura and Hirosi Kuriyama",
year = "1987",
month = "1",
day = "1",
doi = "10.1016/S0735-1097(87)80322-4",
language = "English",
volume = "9",
pages = "1167--1175",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier USA",
number = "5",

}

TY - JOUR

T1 - Regulation of coronary artery tone in relation to the activation of signal transductors that regulate calcium homeostasis

AU - Sasaguri, Toshiyuki

AU - Itoh, Takeo

AU - Hirata, Masato

AU - Kitamura, Kenji

AU - Kuriyama, Hirosi

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Muscle tone of coronary arteries is regulated by free calcium concentration in the myoplasm. Various agonists, autacoids and putative peptides modify the calcium concentration directly or through actions of second messengers (signal transductors), such as cyclic guanosine monophosphate (GMP), cyclic adenosine monophosphate (AMP), inositol 1,4,5-trisphosphate, diacylgly-cerol or calmodulin. For example, acetylcholine (in the presence of intact endothelium cells), alpha-human natriuretic peptide or nitrate compounds increase the amount of cyclic GMP and isoproterenol, prostacyclin (prostaglandin I 2 ) or vasoactive intestinal polypeptide increases cyclic AMP. Both cyclic nucleotides reduce free calcium concentration. On the other hand, acetylcholine (in the presence or absence of endothelium cells), norepinephrine or thromboxane A2 increases inositol 1,4,5-tris-phosphate and diacylglycerol, thus causing the increase in the free calcium concentration, whereas vasoactive intestinal peptide and alpha-human natriuretic peptide reduce them. Calmodulin acts as an internal calcium receptor for regulation of the contractile machinary. Regulation of calcium homeostasis in relation to the muscle tone in the coronary arteries including other vascular tissues is discussed together with the role of second messengers.

AB - Muscle tone of coronary arteries is regulated by free calcium concentration in the myoplasm. Various agonists, autacoids and putative peptides modify the calcium concentration directly or through actions of second messengers (signal transductors), such as cyclic guanosine monophosphate (GMP), cyclic adenosine monophosphate (AMP), inositol 1,4,5-trisphosphate, diacylgly-cerol or calmodulin. For example, acetylcholine (in the presence of intact endothelium cells), alpha-human natriuretic peptide or nitrate compounds increase the amount of cyclic GMP and isoproterenol, prostacyclin (prostaglandin I 2 ) or vasoactive intestinal polypeptide increases cyclic AMP. Both cyclic nucleotides reduce free calcium concentration. On the other hand, acetylcholine (in the presence or absence of endothelium cells), norepinephrine or thromboxane A2 increases inositol 1,4,5-tris-phosphate and diacylglycerol, thus causing the increase in the free calcium concentration, whereas vasoactive intestinal peptide and alpha-human natriuretic peptide reduce them. Calmodulin acts as an internal calcium receptor for regulation of the contractile machinary. Regulation of calcium homeostasis in relation to the muscle tone in the coronary arteries including other vascular tissues is discussed together with the role of second messengers.

UR - http://www.scopus.com/inward/record.url?scp=0023193463&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023193463&partnerID=8YFLogxK

U2 - 10.1016/S0735-1097(87)80322-4

DO - 10.1016/S0735-1097(87)80322-4

M3 - Article

C2 - 3033044

AN - SCOPUS:0023193463

VL - 9

SP - 1167

EP - 1175

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 5

ER -