Regulation of gonadotropin subunit genes expression by 11-ketotestosterone during early spermatogenesis in male red seabream, Pagrus major

S. Yamaguchi, K. Gen, K. Okuzawa, N. Kumakura, H. Kagawa, Michiya Matsuyama

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To examine the roles of gonadal steroids in the regulation of expression of gonadotropin subunit genes, male red seabream were gonadectomized and a sub-group was treated with 11-ketotestosterone (11-KT). Castration of males during the early stage of spermatogenesis elicited a significant increase in FSHβ mRNA levels, which was prevented by 11-KT replacement. By contrast, LHβ mRNA levels were not changed by castration or 11-KT replacement. In addition, administration of 11-KT to sham-operated males suppressed the steady-state FSHβ and LHβ mRNA levels. These results indicate that 11-KT may function as a negative feedback regulator of FSHβ gene expression, and may act through the testis to down-regulate LHβ mRNA levels in male red seabream during this period.

Original languageEnglish
Pages (from-to)111-112
Number of pages2
JournalFish Physiology and Biochemistry
Volume28
Issue number1-4
DOIs
Publication statusPublished - Dec 1 2003

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Sea Bream
Pagrus major
Spermatogenesis
gonadotropins
spermatogenesis
Gonadotropins
Gene expression
gene expression
castration
Gene Expression
Messenger RNA
replacement
steroids
testes
steroid
Orchiectomy
Castration
Regulator Genes
Testis
Down-Regulation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Aquatic Science

Cite this

Regulation of gonadotropin subunit genes expression by 11-ketotestosterone during early spermatogenesis in male red seabream, Pagrus major. / Yamaguchi, S.; Gen, K.; Okuzawa, K.; Kumakura, N.; Kagawa, H.; Matsuyama, Michiya.

In: Fish Physiology and Biochemistry, Vol. 28, No. 1-4, 01.12.2003, p. 111-112.

Research output: Contribution to journalArticle

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