Regulation of hematopoiesis by the osteoblastic niche

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Blood cell production is maintained throughout the lifetime of an individual by hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, known as stem cell niches, is critical for maintaining the stem cell properties, including self-renewal capacity and the ability of differentiation into single or multiple lineages. Recently, it was clarified that a osteoblast is a critical component of the niche for HSCs. HSCs keep balance between quiescence and cell division/proliferation in the osteoblastic niche. The HSC specific properties are dynamically controlled by the signalings of receptors/ligands and cell adhesion molecules produced by osteoblasts.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalClinical calcium
Volume15
Issue number7
Publication statusPublished - Jan 1 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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