Regulation of hematopoietic development by ZBTB transcription factors

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Hematopoietic development is governed by the coordinated expression of lineage- and differentiation stage-specific genes. Transcription factors play major roles in this process and their perturbation may underlie hematologic and immunologic disorders. Nearly 1900 transcription factors are encoded in the human genome: of these, 49 BTB (for broad-complex, tram-track and bric à brac)-zinc finger transcription factors referred to as ZBTB or POK proteins have been identified. ZBTB proteins, including BCL6, PLZF, ThPOK and LRF, exhibit a broad spectrum of functions in normal and malignant hematopoiesis. This review summarizes developmental and molecular functions of ZBTB proteins relevant to hematology.

Original languageEnglish
Pages (from-to)310-323
Number of pages14
JournalInternational journal of hematology
Volume104
Issue number3
DOIs
Publication statusPublished - Sep 1 2016
Externally publishedYes

Fingerprint

Transcription Factors
Proteins
Zinc Fingers
Hematopoiesis
Human Genome
Hematology
Genes

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Regulation of hematopoietic development by ZBTB transcription factors. / Maeda, Takahiro.

In: International journal of hematology, Vol. 104, No. 3, 01.09.2016, p. 310-323.

Research output: Contribution to journalReview article

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