Regulation of immune responses by interleukin-27

Hiroki Yoshida, Yoshiyuki Miyazaki

Research output: Contribution to journalReview article

132 Citations (Scopus)

Abstract

Cytokine-mediated immunity plays a crucial role in the pathogenesis of various diseases including autoimmunity. Recently, interleukin-27 (IL-27) was identified, which, along with IL-12, IL-23, and IL-35, belongs to the IL-12 cytokine family. These family members play roles in the regulation of T helper (Th) cell differentiation. IL-27 is unique in that while it induces Th1 differentiation, the same cytokine suppresses immune responses. In the absence of IL-27-mediated immunosuppression, hyper-production of various pro-inflammatory cytokines concomitant with severe inflammation in affected organs was observed in IL-27 receptor α chain (WSX-1)-deficient mice infected with Trypanosoma cruzi. Experimental allergic or inflammatory responses were also enhanced in WSX-1-deficient mice. The immunosuppressive effects of IL-27 depend on inhibition of the development of Th17 cells (a newly identified inflammatory T-helper population) and induction of IL-10 production. Moreover, administration of IL-27 or augmentation of IL-27 signaling suppresses some diseases of autoimmune or allergic origin, demonstrating its potential in therapy of diseases mediated by inflammatory cytokines. In this review, we discuss recent studies on the role of IL-27 in immunity to parasitic and bacterial infections as well as in allergy and autoimmunity in view of its pro- and anti-inflammatory properties.

Original languageEnglish
Pages (from-to)234-247
Number of pages14
JournalImmunological Reviews
Volume226
Issue number1
DOIs
Publication statusPublished - Dec 1 2008

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Interleukin-27
Cytokines
Interleukin-12
Autoimmunity
Immunity
Interleukin Receptors
Interleukin-23
Th17 Cells
Parasitic Diseases
Trypanosoma cruzi
Immunosuppressive Agents
Bacterial Infections
Interleukin-10
Immunosuppression
Autoimmune Diseases
Cell Differentiation
Hypersensitivity
Anti-Inflammatory Agents
Inflammation

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Regulation of immune responses by interleukin-27. / Yoshida, Hiroki; Miyazaki, Yoshiyuki.

In: Immunological Reviews, Vol. 226, No. 1, 01.12.2008, p. 234-247.

Research output: Contribution to journalReview article

Yoshida, Hiroki ; Miyazaki, Yoshiyuki. / Regulation of immune responses by interleukin-27. In: Immunological Reviews. 2008 ; Vol. 226, No. 1. pp. 234-247.
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