Regulation of myocardial growth and death by NADPH oxidase

Yasuhiro Maejima, Junya Kuroda, Shoji Matsushima, Tetsuro Ago, Junichi Sadoshima

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

The NADPH oxidases (Nox) are transmembrane proteins dedicated to producing reactive oxygen species (ROS), including superoxide and hydrogen peroxide, by transferring electrons from NAD(P)H to molecular oxygen. Nox2 and Nox4 are expressed in the heart and play an important role in mediating oxidative stress at baseline and under stress. Nox2 is primarily localized on the plasma membrane, whereas Nox4 is found primarily on intracellular membranes, on mitochondria, the endoplasmic reticulum or the nucleus. Although Nox2 plays an important role in mediating angiotensin II-induced cardiac hypertrophy, Nox4 mediates cardiac hypertrophy and heart failure in response to pressure overload. Expression of Nox4 is upregulated by hypertrophic stimuli, and Nox4 in mitochondria plays an essential role in mediating oxidative stress during pressure overload-induced cardiac hypertrophy. Upregulation of Nox4 induces oxidation of mitochondrial proteins, including aconitase, thereby causing mitochondrial dysfunction and myocardial cell death. On the other hand, Noxs also appear to mediate physiological functions, such as erythropoiesis and angiogenesis. In this review, we discuss the role of Noxs in mediating oxidative stress and both pathological and physiological functions of Noxs in the heart.

Original languageEnglish
Pages (from-to)408-416
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume50
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

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NADPH Oxidase
Cardiomegaly
Oxidative Stress
Mitochondria
Heart Failure
Growth
Aconitate Hydratase
Pressure
Intracellular Membranes
Erythropoiesis
Mitochondrial Proteins
Superoxides
Angiotensin II
Endoplasmic Reticulum
NAD
Hydrogen Peroxide
Reactive Oxygen Species
Cell Death
Up-Regulation
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Regulation of myocardial growth and death by NADPH oxidase. / Maejima, Yasuhiro; Kuroda, Junya; Matsushima, Shoji; Ago, Tetsuro; Sadoshima, Junichi.

In: Journal of Molecular and Cellular Cardiology, Vol. 50, No. 3, 01.03.2011, p. 408-416.

Research output: Contribution to journalReview article

Maejima, Yasuhiro ; Kuroda, Junya ; Matsushima, Shoji ; Ago, Tetsuro ; Sadoshima, Junichi. / Regulation of myocardial growth and death by NADPH oxidase. In: Journal of Molecular and Cellular Cardiology. 2011 ; Vol. 50, No. 3. pp. 408-416.
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