Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films

Akinori Tsuruma, Masaru Tanaka, Nobuyuki Fukushima, Sadaaki Yamamoto, Masatsugu Shimomura

Research output: Contribution to conferencePaper

Abstract

We have succeeded in preparing porous biodegradable polymer films with highly regular aligned pores in the shape of honeycomb (honeycomb film) by a simple casting method. In this report, we cultured NSCs on honeycomb films (pore size, 3, 5, 8, and 10 μm) and investigated influences of the pore size on differentiation and proliferation of NSCs. On honeycomb films with pore size of > 5 μm, NSCs differentiated into neurons. The neurons extended neurites along the honeycomb patterns, and neurite morphological changes depended on pore size of honeycomb films. On the other hands, NSCs proliferated and formed spheroids on the honeycomb films with pore size of 3 μm. This study shows that the honeycomb films are potential scaffolds for neural tissue engineering.

Original languageEnglish
Number of pages1
Publication statusPublished - Oct 19 2006
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: May 24 2006May 26 2006

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period5/24/065/26/06

Fingerprint

Stem cells
Pore size
Neurons
Biodegradable polymers
Bioelectric potentials
Scaffolds (biology)
Tissue engineering
Polymer films
Casting

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Tsuruma, A., Tanaka, M., Fukushima, N., Yamamoto, S., & Shimomura, M. (2006). Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films. / Tsuruma, Akinori; Tanaka, Masaru; Fukushima, Nobuyuki; Yamamoto, Sadaaki; Shimomura, Masatsugu.

2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

Research output: Contribution to conferencePaper

Tsuruma, A, Tanaka, M, Fukushima, N, Yamamoto, S & Shimomura, M 2006, 'Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films', Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan, 5/24/06 - 5/26/06.
Tsuruma A, Tanaka M, Fukushima N, Yamamoto S, Shimomura M. Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films. 2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.
Tsuruma, Akinori ; Tanaka, Masaru ; Fukushima, Nobuyuki ; Yamamoto, Sadaaki ; Shimomura, Masatsugu. / Regulation of neural stem cell differentiation and proliferation by self-organized honeycomb-patterned films. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.1 p.
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