Regulation of NF-κB-dependent T cell activation and development by MEKK3

Hisaaki Shinohara, Shou Yamasaki, Shiori Maeda, Takashi Saito, Tomohiro Kurosaki

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    The serine/threonine kinase MEKK3, also known as mitogen-activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-κB in innate immunity. However, the physiological function of MEKK3 in adaptive immunity is unclear. Here we report that following TCR signaling, MEKK3 positively regulated the kinase, IκB kinase, leading to NF-κB activation. T cells lacking MEKK3 were defective in TCR-induced and cytokine-induced responses. Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity.

    Original languageEnglish
    Pages (from-to)393-401
    Number of pages9
    JournalInternational Immunology
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - Apr 8 2009

    Fingerprint

    Adaptive Immunity
    T-Lymphocytes
    MAP Kinase Kinase Kinase 3
    Phosphotransferases
    Protein-Serine-Threonine Kinases
    Thymocytes
    Innate Immunity
    Transcription Factors
    Cytokines

    All Science Journal Classification (ASJC) codes

    • Immunology

    Cite this

    Shinohara, H., Yamasaki, S., Maeda, S., Saito, T., & Kurosaki, T. (2009). Regulation of NF-κB-dependent T cell activation and development by MEKK3. International Immunology, 21(4), 393-401. https://doi.org/10.1093/intimm/dxp007

    Regulation of NF-κB-dependent T cell activation and development by MEKK3. / Shinohara, Hisaaki; Yamasaki, Shou; Maeda, Shiori; Saito, Takashi; Kurosaki, Tomohiro.

    In: International Immunology, Vol. 21, No. 4, 08.04.2009, p. 393-401.

    Research output: Contribution to journalArticle

    Shinohara, H, Yamasaki, S, Maeda, S, Saito, T & Kurosaki, T 2009, 'Regulation of NF-κB-dependent T cell activation and development by MEKK3', International Immunology, vol. 21, no. 4, pp. 393-401. https://doi.org/10.1093/intimm/dxp007
    Shinohara, Hisaaki ; Yamasaki, Shou ; Maeda, Shiori ; Saito, Takashi ; Kurosaki, Tomohiro. / Regulation of NF-κB-dependent T cell activation and development by MEKK3. In: International Immunology. 2009 ; Vol. 21, No. 4. pp. 393-401.
    @article{728f6ad6da0c4faba8b3f3d1eff86e1c,
    title = "Regulation of NF-κB-dependent T cell activation and development by MEKK3",
    abstract = "The serine/threonine kinase MEKK3, also known as mitogen-activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-κB in innate immunity. However, the physiological function of MEKK3 in adaptive immunity is unclear. Here we report that following TCR signaling, MEKK3 positively regulated the kinase, IκB kinase, leading to NF-κB activation. T cells lacking MEKK3 were defective in TCR-induced and cytokine-induced responses. Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity.",
    author = "Hisaaki Shinohara and Shou Yamasaki and Shiori Maeda and Takashi Saito and Tomohiro Kurosaki",
    year = "2009",
    month = "4",
    day = "8",
    doi = "10.1093/intimm/dxp007",
    language = "English",
    volume = "21",
    pages = "393--401",
    journal = "International Immunology",
    issn = "0953-8178",
    publisher = "Oxford University Press",
    number = "4",

    }

    TY - JOUR

    T1 - Regulation of NF-κB-dependent T cell activation and development by MEKK3

    AU - Shinohara, Hisaaki

    AU - Yamasaki, Shou

    AU - Maeda, Shiori

    AU - Saito, Takashi

    AU - Kurosaki, Tomohiro

    PY - 2009/4/8

    Y1 - 2009/4/8

    N2 - The serine/threonine kinase MEKK3, also known as mitogen-activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-κB in innate immunity. However, the physiological function of MEKK3 in adaptive immunity is unclear. Here we report that following TCR signaling, MEKK3 positively regulated the kinase, IκB kinase, leading to NF-κB activation. T cells lacking MEKK3 were defective in TCR-induced and cytokine-induced responses. Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity.

    AB - The serine/threonine kinase MEKK3, also known as mitogen-activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-κB in innate immunity. However, the physiological function of MEKK3 in adaptive immunity is unclear. Here we report that following TCR signaling, MEKK3 positively regulated the kinase, IκB kinase, leading to NF-κB activation. T cells lacking MEKK3 were defective in TCR-induced and cytokine-induced responses. Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity.

    UR - http://www.scopus.com/inward/record.url?scp=63649162155&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=63649162155&partnerID=8YFLogxK

    U2 - 10.1093/intimm/dxp007

    DO - 10.1093/intimm/dxp007

    M3 - Article

    VL - 21

    SP - 393

    EP - 401

    JO - International Immunology

    JF - International Immunology

    SN - 0953-8178

    IS - 4

    ER -