Regulation of NF-κB-dependent T cell activation and development by MEKK3

Hisaaki Shinohara, Sho Yamasaki, Shiori Maeda, Takashi Saito, Tomohiro Kurosaki

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    The serine/threonine kinase MEKK3, also known as mitogen-activated protein kinase kinase kinase 3, is a critical activator of the transcription factor NF-κB in innate immunity. However, the physiological function of MEKK3 in adaptive immunity is unclear. Here we report that following TCR signaling, MEKK3 positively regulated the kinase, IκB kinase, leading to NF-κB activation. T cells lacking MEKK3 were defective in TCR-induced and cytokine-induced responses. Furthermore, T cell-specific deletion of MEKK3 resulted in reduced numbers of thymocytes and peripheral T cells. Thus, our results provide genetic evidence that MEKK3 plays a crucial role in adaptive immunity.

    Original languageEnglish
    Pages (from-to)393-401
    Number of pages9
    JournalInternational immunology
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - 2009

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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