Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3

Sakae Tanaka, Hidetoshi Wakeyama, Toru Akiyama, Katsuhiko Takahashi, Hitoshi Amano, Keiichi I. Nakayama, Kozo Nakamura

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

15 Citations (Scopus)

Abstract

Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

Original languageEnglish
Title of host publicationOsteoimmunology
Subtitle of host publicationInteractions of the Immune and Skeletal Systems II
EditorsYongwon Choi
Pages111-116
Number of pages6
DOIs
Publication statusPublished - Dec 1 2010

Publication series

NameAdvances in Experimental Medicine and Biology
Volume658
ISSN (Print)0065-2598

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Osteoclasts
Caspase 3
Apoptosis
Proteins
Chemical activation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tanaka, S., Wakeyama, H., Akiyama, T., Takahashi, K., Amano, H., Nakayama, K. I., & Nakamura, K. (2010). Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. In Y. Choi (Ed.), Osteoimmunology: Interactions of the Immune and Skeletal Systems II (pp. 111-116). (Advances in Experimental Medicine and Biology; Vol. 658). https://doi.org/10.1007/978-1-4419-1050-9_12

Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. / Tanaka, Sakae; Wakeyama, Hidetoshi; Akiyama, Toru; Takahashi, Katsuhiko; Amano, Hitoshi; Nakayama, Keiichi I.; Nakamura, Kozo.

Osteoimmunology: Interactions of the Immune and Skeletal Systems II. ed. / Yongwon Choi. 2010. p. 111-116 (Advances in Experimental Medicine and Biology; Vol. 658).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tanaka, S, Wakeyama, H, Akiyama, T, Takahashi, K, Amano, H, Nakayama, KI & Nakamura, K 2010, Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. in Y Choi (ed.), Osteoimmunology: Interactions of the Immune and Skeletal Systems II. Advances in Experimental Medicine and Biology, vol. 658, pp. 111-116. https://doi.org/10.1007/978-1-4419-1050-9_12
Tanaka S, Wakeyama H, Akiyama T, Takahashi K, Amano H, Nakayama KI et al. Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. In Choi Y, editor, Osteoimmunology: Interactions of the Immune and Skeletal Systems II. 2010. p. 111-116. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1050-9_12
Tanaka, Sakae ; Wakeyama, Hidetoshi ; Akiyama, Toru ; Takahashi, Katsuhiko ; Amano, Hitoshi ; Nakayama, Keiichi I. ; Nakamura, Kozo. / Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. Osteoimmunology: Interactions of the Immune and Skeletal Systems II. editor / Yongwon Choi. 2010. pp. 111-116 (Advances in Experimental Medicine and Biology).
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