TY - GEN
T1 - Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3
AU - Tanaka, Sakae
AU - Wakeyama, Hidetoshi
AU - Akiyama, Toru
AU - Takahashi, Katsuhiko
AU - Amano, Hitoshi
AU - Nakayama, Keiichi I.
AU - Nakamura, Kozo
PY - 2010
Y1 - 2010
N2 - Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
AB - Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
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UR - http://www.scopus.com/inward/citedby.url?scp=79958817476&partnerID=8YFLogxK
U2 - 10.1007/978-1-4419-1050-9_12
DO - 10.1007/978-1-4419-1050-9_12
M3 - Conference contribution
C2 - 19950021
AN - SCOPUS:79958817476
SN - 9781441910493
T3 - Advances in Experimental Medicine and Biology
SP - 111
EP - 116
BT - Osteoimmunology
A2 - Choi, Yongwon
ER -