Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
|Title of host publication||Osteoimmunology|
|Subtitle of host publication||Interactions of the Immune and Skeletal Systems II|
|Number of pages||6|
|Publication status||Published - 2010|
|Name||Advances in Experimental Medicine and Biology|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)