TY - GEN
T1 - Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3
AU - Tanaka, Sakae
AU - Wakeyama, Hidetoshi
AU - Akiyama, Toru
AU - Takahashi, Katsuhiko
AU - Amano, Hitoshi
AU - Nakayama, Keiichi I.
AU - Nakamura, Kozo
N1 - Funding Information:
This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Health Science research grants from the Ministry of Health, Labor, and Welfare of Japan to S.T.
PY - 2010
Y1 - 2010
N2 - Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
AB - Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
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U2 - 10.1007/978-1-4419-1050-9_12
DO - 10.1007/978-1-4419-1050-9_12
M3 - Conference contribution
C2 - 19950021
AN - SCOPUS:79958817476
SN - 9781441910493
T3 - Advances in Experimental Medicine and Biology
SP - 111
EP - 116
BT - Osteoimmunology
A2 - Choi, Yongwon
ER -