Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3

Sakae Tanaka; Hidetoshi Wakeyama; Toru Akiyama; Katsuhiko Takahashi; Hitoshi Amano; Keiichi I. Nakayama; Kozo Nakamura

doi:10.1007/978-1-4419-1050-9_12

Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3

Sakae Tanaka, Hidetoshi Wakeyama, Toru Akiyama, Katsuhiko Takahashi, Hitoshi Amano, Keiichi I. Nakayama, Kozo Nakamura

Department of Molecular and Cellular Biology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

15 Citations (Scopus)

Abstract

Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.

Original language	English
Title of host publication	Osteoimmunology
Subtitle of host publication	Interactions of the Immune and Skeletal Systems II
Editors	Yongwon Choi
Pages	111-116
Number of pages	6
DOIs	https://doi.org/10.1007/978-1-4419-1050-9_12
Publication status	Published - 2010

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	658
ISSN (Print)	0065-2598

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1007/978-1-4419-1050-9_12

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Tanaka, S., Wakeyama, H., Akiyama, T., Takahashi, K., Amano, H., Nakayama, K. I., & Nakamura, K. (2010). Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. In Y. Choi (Ed.), Osteoimmunology: Interactions of the Immune and Skeletal Systems II (pp. 111-116). (Advances in Experimental Medicine and Biology; Vol. 658). https://doi.org/10.1007/978-1-4419-1050-9_12

Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. / Tanaka, Sakae; Wakeyama, Hidetoshi; Akiyama, Toru; Takahashi, Katsuhiko; Amano, Hitoshi; Nakayama, Keiichi I.; Nakamura, Kozo.

Osteoimmunology: Interactions of the Immune and Skeletal Systems II. ed. / Yongwon Choi. 2010. p. 111-116 (Advances in Experimental Medicine and Biology; Vol. 658).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tanaka, S, Wakeyama, H, Akiyama, T, Takahashi, K, Amano, H, Nakayama, KI & Nakamura, K 2010, Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. in Y Choi (ed.), Osteoimmunology: Interactions of the Immune and Skeletal Systems II. Advances in Experimental Medicine and Biology, vol. 658, pp. 111-116. https://doi.org/10.1007/978-1-4419-1050-9_12

Tanaka, Sakae ; Wakeyama, Hidetoshi ; Akiyama, Toru ; Takahashi, Katsuhiko ; Amano, Hitoshi ; Nakayama, Keiichi I. ; Nakamura, Kozo. / Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. Osteoimmunology: Interactions of the Immune and Skeletal Systems II. editor / Yongwon Choi. 2010. pp. 111-116 (Advances in Experimental Medicine and Biology).

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