Regulation of steroidogenesis in transgenic mice and zebrafish

Meng Chun Hu, Evelyn Feng Lin Chiang, Sok Keng Tong, Wayne Lai, Nai Chi Hsu, Leo Chi Kwang Wang, Bon chu Chung

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Steroid hormones are important physiological regulators in the body. Steroid hormones are mainly synthesized in the adrenal and gonads. Their synthesis is stimulated by pituitary hormones through cAMP as an intracellular mediator. The first and rate-limiting step for steroid biosynthesis is catalyzed by CYP11A1. Important regulatory elements for the control of the CYP11A1 gene expression have been characterized both in vitro and in vivo. The SF-1-binding sites are cis-acting elements controlling the basal and cAMP-stimulated gene expression. Our transgenic mouse studies showed that the 2.3kb promoter contains information controlling developmentally regulated gene expression. Finally, we present our results on the cloning of steroidogenic genes in zebrafish, a new model organism for genetic studies.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume171
Issue number1-2
DOIs
Publication statusPublished - Jan 22 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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