Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins

Kenta Shigetomi, Junichi Ikenouchi

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Body and organ surfaces in multicellular organisms are covered with a sheet of epithelial cells. The tight junction (TJ) is an adhesive structure that seals the gap between epithelial cells and functions as a selective barrier to prevent the entry of antigens and pathogenic microbes from the extracellular environment. Several transmembrane proteins that constitute the TJ (claudin, occludin, tricellulin and angulin) have been identified. As over-expression of these proteins does not enlarge TJs or enhance epithelial barrier function, it remains unclear how TJ membrane proteins are regulated to modulate the amount of TJ and the strength of the epithelial barrier. In this review, we discuss the posttranslational modifications of TJ membrane proteins and their physiological significance from the viewpoint of the dynamic regulation of the epithelial barrier.

Original languageEnglish
Pages (from-to)265-272
Number of pages8
JournalJournal of biochemistry
Volume163
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

Fingerprint

Tight Junction Proteins
Post Translational Protein Processing
MARVEL Domain Containing 2 Protein
Membrane Proteins
Tight Junctions
Occludin
Epithelial Cells
Seals
Adhesives
Antigens
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins. / Shigetomi, Kenta; Ikenouchi, Junichi.

In: Journal of biochemistry, Vol. 163, No. 4, 01.04.2018, p. 265-272.

Research output: Contribution to journalReview article

@article{09c5888b6d0b46e5b48b9a894d2be1a6,
title = "Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins",
abstract = "Body and organ surfaces in multicellular organisms are covered with a sheet of epithelial cells. The tight junction (TJ) is an adhesive structure that seals the gap between epithelial cells and functions as a selective barrier to prevent the entry of antigens and pathogenic microbes from the extracellular environment. Several transmembrane proteins that constitute the TJ (claudin, occludin, tricellulin and angulin) have been identified. As over-expression of these proteins does not enlarge TJs or enhance epithelial barrier function, it remains unclear how TJ membrane proteins are regulated to modulate the amount of TJ and the strength of the epithelial barrier. In this review, we discuss the posttranslational modifications of TJ membrane proteins and their physiological significance from the viewpoint of the dynamic regulation of the epithelial barrier.",
author = "Kenta Shigetomi and Junichi Ikenouchi",
year = "2018",
month = "4",
day = "1",
doi = "10.1093/jb/mvx077",
language = "English",
volume = "163",
pages = "265--272",
journal = "Journal of Biochemistry",
issn = "0021-924X",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Regulation of the epithelial barrier by post-translational modifications of tight junction membrane proteins

AU - Shigetomi, Kenta

AU - Ikenouchi, Junichi

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Body and organ surfaces in multicellular organisms are covered with a sheet of epithelial cells. The tight junction (TJ) is an adhesive structure that seals the gap between epithelial cells and functions as a selective barrier to prevent the entry of antigens and pathogenic microbes from the extracellular environment. Several transmembrane proteins that constitute the TJ (claudin, occludin, tricellulin and angulin) have been identified. As over-expression of these proteins does not enlarge TJs or enhance epithelial barrier function, it remains unclear how TJ membrane proteins are regulated to modulate the amount of TJ and the strength of the epithelial barrier. In this review, we discuss the posttranslational modifications of TJ membrane proteins and their physiological significance from the viewpoint of the dynamic regulation of the epithelial barrier.

AB - Body and organ surfaces in multicellular organisms are covered with a sheet of epithelial cells. The tight junction (TJ) is an adhesive structure that seals the gap between epithelial cells and functions as a selective barrier to prevent the entry of antigens and pathogenic microbes from the extracellular environment. Several transmembrane proteins that constitute the TJ (claudin, occludin, tricellulin and angulin) have been identified. As over-expression of these proteins does not enlarge TJs or enhance epithelial barrier function, it remains unclear how TJ membrane proteins are regulated to modulate the amount of TJ and the strength of the epithelial barrier. In this review, we discuss the posttranslational modifications of TJ membrane proteins and their physiological significance from the viewpoint of the dynamic regulation of the epithelial barrier.

UR - http://www.scopus.com/inward/record.url?scp=85044994328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044994328&partnerID=8YFLogxK

U2 - 10.1093/jb/mvx077

DO - 10.1093/jb/mvx077

M3 - Review article

VL - 163

SP - 265

EP - 272

JO - Journal of Biochemistry

JF - Journal of Biochemistry

SN - 0021-924X

IS - 4

ER -