TY - JOUR
T1 - Regulation of the neural niche by the soluble molecule Akhirin
AU - Acharjee, Uzzal Kumar
AU - Felemban, Athary Abdulhaleem
AU - Riyadh, Asrafuzzaman M.
AU - Ohta, Kunimasa
N1 - Funding Information:
We thank Naofumi Ito and Adil Ishtiyaq for their critical comments, and all members of our labs for their valuable help. This work was supported by the Precursory Research for Embryonic Science and Technology program of the Japan Science and Technology Agency (K.O.), and Grants-in-Aid for Scientific Research on Molecular Brain Science from the Ministry of Education Culture, Sports, Science, and Technology of Japan (K.O.), the Global COE Program (Cell Fate Regulation Research and Education Unit) (K.O.), and the Program for Leading Graduate Schools “HIGO (Health Life Science: Interdisciplinary and Glocal Oriented)”, MEXT, Japan (UKA).
Publisher Copyright:
© 2016 Japanese Society of Developmental Biologists
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Though the adult central nervous system has been considered a comparatively static tissue with little turnover, it is well established today that new neural cells are generated throughout life. Neural stem/progenitor cells (NS/PCs) can self-renew and generate all types of neural cells. The proliferation of NS/PCs, and differentiation and fate determination of PCs are regulated by extrinsic factors such as growth factors, neurotrophins, and morphogens. Although several extrinsic factors that influence neurogenesis have already been reported, little is known about the role of soluble molecules in neural niche regulation. In this review, we will introduce the soluble molecule Akhirin and discuss its role in the eye and spinal cord during development.
AB - Though the adult central nervous system has been considered a comparatively static tissue with little turnover, it is well established today that new neural cells are generated throughout life. Neural stem/progenitor cells (NS/PCs) can self-renew and generate all types of neural cells. The proliferation of NS/PCs, and differentiation and fate determination of PCs are regulated by extrinsic factors such as growth factors, neurotrophins, and morphogens. Although several extrinsic factors that influence neurogenesis have already been reported, little is known about the role of soluble molecules in neural niche regulation. In this review, we will introduce the soluble molecule Akhirin and discuss its role in the eye and spinal cord during development.
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U2 - 10.1111/dgd.12284
DO - 10.1111/dgd.12284
M3 - Review article
C2 - 27134067
AN - SCOPUS:84964575191
SN - 0012-1592
VL - 58
SP - 463
EP - 468
JO - Development Growth and Differentiation
JF - Development Growth and Differentiation
IS - 5
ER -