Regulation of the replication cycle: Conserved and diverse regulatory systems for DnaA and oriC

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu

Research output: Contribution to journalReview article

183 Citations (Scopus)

Abstract

Chromosomal replication must be limited to once and only once per cell cycle. This is accomplished by multiple regulatory pathways that govern initiator proteins and replication origins. A principal feature of DNA replication is the coupling of the replication reaction to negative-feedback regulation. Some of the factors that are important in this process have been discovered, including the clamp (DNA polymerase III subunit-Β (DnaN)), the datA locus, SeqA, DnaA homologue protein (Hda) and YabA, as well as factors that are involved at other stages of the regulatory mechanism, such as DnaA initiator-associating protein (DiaA), the DnaA-reactivating sequence (DARS) loci and Soj. Here, we describe the regulation of DnaA, one of the central proteins involved in bacterial DNA replication, by these factors in Escherichia coli, Bacillus subtilis and Caulobacter crescentus.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalNature Reviews Microbiology
Volume8
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

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DNA Replication
Proteins
Caulobacter crescentus
DNA Polymerase III
Bacterial DNA
Replication Origin
Bacillus subtilis
Cell Cycle
Escherichia coli

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)

Cite this

Regulation of the replication cycle : Conserved and diverse regulatory systems for DnaA and oriC. / Katayama, Tsutomu; Ozaki, Shogo; Keyamura, Kenji; Fujimitsu, Kazuyuki.

In: Nature Reviews Microbiology, Vol. 8, No. 3, 01.03.2010, p. 163-170.

Research output: Contribution to journalReview article

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