Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma

Report of six cases

Hideyuki Murata, Yoshihiro Adachi, Takehiko Ebitsuka, Yusuke Chino, Reiko Takahashi, Taichi Hayashi, Daisuke Goto, Isao Matsumoto, Akito Tsutsumi, Hideyuki Akaza, Takayuki Sumida

Research output: Contribution to journalArticle

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Abstract

We report the cases of six patients who developed acute Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin (BCG) immunotherapy for superficial bladder cancer. After the third to eighth BCG intravesical injection, the patients developed conjunctivitis, aseptic urethritis, and polyarthritis consistent with a diagnosis of Reiter's syndrome. HLA-B27 antigen was negative in five of the patients examined. Two of the patients responded to nonsteroidal anti-inflammatory drugs for polyarthritis, and the other four responded to steroids (prednisolone 5-10mg/day). The frequent use of intracavitary BCG may increase the incidence of BCG-induced Reiter's syndrome. Further analysis of the relationship between HLA-B and -DR alleles and arthritis should shed light on the mechanism of BCG-induced Reiter's syndrome.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalModern Rheumatology
Volume14
Issue number1
DOIs
Publication statusPublished - Mar 1 2004

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Reactive Arthritis
Urinary Bladder
Arthritis
Carcinoma
Intravesical Administration
HLA-B27 Antigen
Urethritis
Conjunctivitis
HLA-B Antigens
HLA-DR Antigens
Therapeutics
Prednisolone
Urinary Bladder Neoplasms
Immunotherapy
Anti-Inflammatory Agents
Alleles
Steroids
Incidence
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma : Report of six cases. / Murata, Hideyuki; Adachi, Yoshihiro; Ebitsuka, Takehiko; Chino, Yusuke; Takahashi, Reiko; Hayashi, Taichi; Goto, Daisuke; Matsumoto, Isao; Tsutsumi, Akito; Akaza, Hideyuki; Sumida, Takayuki.

In: Modern Rheumatology, Vol. 14, No. 1, 01.03.2004, p. 82-86.

Research output: Contribution to journalArticle

Murata, H, Adachi, Y, Ebitsuka, T, Chino, Y, Takahashi, R, Hayashi, T, Goto, D, Matsumoto, I, Tsutsumi, A, Akaza, H & Sumida, T 2004, 'Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma: Report of six cases', Modern Rheumatology, vol. 14, no. 1, pp. 82-86. https://doi.org/10.1007/s10165-003-0272-3
Murata, Hideyuki ; Adachi, Yoshihiro ; Ebitsuka, Takehiko ; Chino, Yusuke ; Takahashi, Reiko ; Hayashi, Taichi ; Goto, Daisuke ; Matsumoto, Isao ; Tsutsumi, Akito ; Akaza, Hideyuki ; Sumida, Takayuki. / Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma : Report of six cases. In: Modern Rheumatology. 2004 ; Vol. 14, No. 1. pp. 82-86.
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