TY - JOUR
T1 - Relationship between aqueous flare and visual function in retinitis pigmentosa
AU - Murakami, Yusuke
AU - Yoshida, Noriko
AU - Ikeda, Yasuhiro
AU - Nakatake, Shunji
AU - Fujiwara, Kota
AU - Notomi, Shoji
AU - Nabeshima, Takahiro
AU - nakao, shintaro
AU - Hisatomi, Toshio
AU - Enaida, Hiroshi
AU - Ishibashi, Tatsuro
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. Funding/Support: This work was supported by the Japanese Ministry of Education, Culture, Sports, Science, and Technology , grants # 25861637 (to Y.M.) and # 24659764 (to T.I.). The authors indicate no conflict of interest associated with this study. Contributions of authors: conception and design (Y.I.); analysis and interpretation (Y.M., N.Y., Y.I., K.F.); writing the article (Y.M., Y.I.); final approval of the article (Y.I., T.I.); data collection (Y.M., N.Y., Y.I., S. Nakatake, K.F., S. Notomi, T.N., S. Nakao, T.H., H.E.); statistical expertise (K.F.); obtaining funding (Y.M., T.I.); literature search (Y.M., N.Y., Y.I.).
Publisher Copyright:
© 2015 by Elsevier Inc. All rights reserved.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Purpose To investigate the correlation between aqueous flare values and central visual function in patients with retinitis pigmentosa (RP). Design Retrospective, observational case series. Methods We retrospectively studied 160 patients diagnosed with typical RP and 59 control subjects. Aqueous flare values were measured by laser flare cell meter. The relationships between aqueous flare and best-corrected visual acuity (VA) and mean deviation (MD) of static perimetry tests were analyzed in RP patients. Results The aqueous flare values were significantly higher in the RP patients compared to the control subjects (10.6 ± 7.9 vs 5.0 ± 2.1 photon counts per millisecond [pc/ms], P <.0001). In the RP patients, the aqueous flare values were negatively correlated with VA (r = 0.359, P <.0001) and MD (r = -0.330, P <.0001). Age-subgroup analysis showed a significant correlation between aqueous flare and VA in the RP patients' 40s, 50s, and 60s and between aqueous flare and MD in the 30s, 40s, 50s, and 60s. The RP patients with MD values ≥-15 decibels (dB) showed significantly higher levels of aqueous flare than those with MD values <-15 dB (12.0 ± 6.2 vs 8.7 ± 5.8, P =.0001). Conclusions Aqueous flare is increased in RP patients and negatively correlates with central visual function. These results suggest a close relationship between inflammation and central vision loss in RP.
AB - Purpose To investigate the correlation between aqueous flare values and central visual function in patients with retinitis pigmentosa (RP). Design Retrospective, observational case series. Methods We retrospectively studied 160 patients diagnosed with typical RP and 59 control subjects. Aqueous flare values were measured by laser flare cell meter. The relationships between aqueous flare and best-corrected visual acuity (VA) and mean deviation (MD) of static perimetry tests were analyzed in RP patients. Results The aqueous flare values were significantly higher in the RP patients compared to the control subjects (10.6 ± 7.9 vs 5.0 ± 2.1 photon counts per millisecond [pc/ms], P <.0001). In the RP patients, the aqueous flare values were negatively correlated with VA (r = 0.359, P <.0001) and MD (r = -0.330, P <.0001). Age-subgroup analysis showed a significant correlation between aqueous flare and VA in the RP patients' 40s, 50s, and 60s and between aqueous flare and MD in the 30s, 40s, 50s, and 60s. The RP patients with MD values ≥-15 decibels (dB) showed significantly higher levels of aqueous flare than those with MD values <-15 dB (12.0 ± 6.2 vs 8.7 ± 5.8, P =.0001). Conclusions Aqueous flare is increased in RP patients and negatively correlates with central visual function. These results suggest a close relationship between inflammation and central vision loss in RP.
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U2 - 10.1016/j.ajo.2015.02.001
DO - 10.1016/j.ajo.2015.02.001
M3 - Article
C2 - 25677184
AN - SCOPUS:84927581371
SN - 0002-9394
VL - 159
SP - 958-963.e1
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 5
M1 - 9233
ER -