Relationship between body surface area and ALT normalization after long-term lamivudine treatment

Makoto Nakamuta, Shusuke Morizono, Yuichi Tanabe, Eije Kajiwara, Junya Shimono, Akihide Masumoto, Toshihiro Maruyama, Norihiro Furusyo, Hideyuki Nomura, Hironori Sakai, Kazuhiro Takahashi, Koichi Azuma, Shinji Shimoda, Kazuhiro Kotoh, Munechika Enjoji, Jun Hayashi

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Abstract

Aim: To further evaluate the relationship between BSA and the effects of lamivudine in a greater number of cases and over a longer period of observation than in our previous evaluation. Methods: We evaluated 249 patients with chronic hepatitis B. The effects of treatment for one year (n = 249), two years (n = 147), and three years (n = 72) were evaluated from the levels of serum ALT and HBV-DNA, as biological and virological effects (undetectable levels by PCR), respectively. Moreover, several variables that could influence the response to treatment, including ALT, albumin, bilirubin, platelet counts, BSA, HBV-DNA, and HBeAg were analyzed. Results: For 1-year treatment, multivariate analysis revealed that BSA (P = 0.0002) was the only factor for the biological effect, and that ALT (P = 0.0017), HBV-DNA (P = 0.0004), and HBeAg (P = 0.0021) were independent factors for the virological effect. For 2-year treatment, multivariate analysis again showed that BSA (P = 0.0147) was the only factor for the biological effect, and that ALT (P = 0.0192) and HBeAg (P = 0.0428) were independent factors for the virological effect. For 3-year treatment, multivariate analysis, however, could not reveal BSA (P = 0.0730) as a factor for the normalization of ALT levels. Conclusion: BSA is a significant predictor for the normalizing the effect of lamivudine therapy on ALT for an initial 2-year period, suggesting that lamivudine dosage should be based on the individual BSA.

Original languageEnglish
Pages (from-to)6948-6953
Number of pages6
JournalWorld Journal of Gastroenterology
Volume11
Issue number44
DOIs
Publication statusPublished - Nov 28 2005

All Science Journal Classification (ASJC) codes

  • Gastroenterology

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    Nakamuta, M., Morizono, S., Tanabe, Y., Kajiwara, E., Shimono, J., Masumoto, A., Maruyama, T., Furusyo, N., Nomura, H., Sakai, H., Takahashi, K., Azuma, K., Shimoda, S., Kotoh, K., Enjoji, M., & Hayashi, J. (2005). Relationship between body surface area and ALT normalization after long-term lamivudine treatment. World Journal of Gastroenterology, 11(44), 6948-6953. https://doi.org/10.3748/wjg.v11.i44.6948