Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in post-menopausal Japanese women

Takayuki Nishimura, Kazuhiko Arima, Yasuyo Abe, Mitsuo Kanagae, Satoshi Mizukami, Takuhiro Okabe, Yoshihito Tomita, Hisashi Goto, Maiko Hasegawa, Yoko Sou, Itsuko Horiguchi, Kiyoshi Aoyagi

Research output: Contribution to journalArticle

Abstract

Background: Osteoporosis in women is a serious health problem. The relationships between biochemical markers of bone turnover and bone mineral density (BMD) in women have been reported, but no study has examined relationships between tartrate-resistant acid phosphatase-5b (TRACP-5b) or bone-specific alkaline phosphatase (BAP) and bone mass measured by quantitative ultrasound (QUS) in Japanese post-menopausal women. Aim: To investigate the serum TRACP-5b and BAP levels and to determine their associations with the heel stiffness index measured by QUS in post-menopausal women. Subjects and methods: The subjects were 510 post-menopausal women who were invited to participate in periodic health examinations in 2011–2013 (the Unzen Study). The heel stiffness index (bone mass) was measured by QUS. Serum samples were collected and TRACP-5b and BAP levels were measured. Results: Multiple regression analysis showed that a higher log (TRACP-5b) was correlated with a lower stiffness index (p = 0.014) and log (BAP) was not correlated with stiffness index after adjusting for covariates (p = 0.136). Conclusion: Higher rates of bone resorption are associated with a lower stiffness index in Japanese post-menopausal women. These results may indicate that high bone resorption affects bone mass more than bone formation, resulting in a low bone mass.

Original languageEnglish
Pages (from-to)330-334
Number of pages5
JournalAnnals of Human Biology
Volume46
Issue number4
DOIs
Publication statusPublished - May 19 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Physiology
  • Ageing
  • Genetics
  • Public Health, Environmental and Occupational Health

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    Nishimura, T., Arima, K., Abe, Y., Kanagae, M., Mizukami, S., Okabe, T., Tomita, Y., Goto, H., Hasegawa, M., Sou, Y., Horiguchi, I., & Aoyagi, K. (2019). Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in post-menopausal Japanese women. Annals of Human Biology, 46(4), 330-334. https://doi.org/10.1080/03014460.2019.1607552