Relationship between both IQ and Mini-Mental state examination and the regional cerebral glucose metabolism in clinically diagnosed Alzheimer's disease: A PET study

Masami Kawano, Atsushi Ichimiya, Koji Ogomori, Yasuo Kuwabara, Masayuki Sasaki, Tsuyoshi Yoshida, Nobutada Tashiro

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

In order to clarify the hypofunction in which brain areas demonstrate a decline in Intelligence Quotient (IQ), we examined correlations between the IQ and Mini-Mental State Examination (MMSE) and regional cerebral metabolic rate of glucose (rCMRglc) measured using positron emission tomography (PET) in 26 patients with clinically diagnosed Alzheimer's disease (AD). The MMSE scores and full-scale IQ (FSIQ) showed significant correlations with the rCMRglc in the temporal and parietal lobes on both sides and in the left frontal lobe, which were significantly reduced in comparison to those in the normal controls. A multiple regression analysis showed only the MMSE score to predict verbal IQ (VIQ), performance IQ (PIQ) and FSIQ. VIQ was also predicted by the rCMRglc in the left parietal lobe, while PIQ was predicted by the age at onset. The results suggested MMSE to be an index of dementia severity reflected by general intelligence as shown by IQ in AD, and a reduction in the VIQ can thus be used as an index of the left parietal dysfunction, which is not expressed by MMSE.

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume12
Issue number2
DOIs
Publication statusPublished - 2001

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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