Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells

Hiroshi Takane, Shigehiro Ohdo, Tomoko Yamada, Koyanagi Satoru, Eiji Yukawa, Shun Higuchi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Whether the diurnal rhythm of cell cycle is associated with that of interferon-α/β receptor (IFNAR) expression was investigated in implanted-tumor cells. The expression of IFNAR mRNA significantly increased when the proportion of tumor cells in DNA synthesis (S) phase increased in vitro. A diurnal rhythm was observed for cell cycle distribution in implanted-tumor cells. The specific binding of interferon-α to receptor and IFNAR mRNA increased when the proportion of tumor cells in S phase increased in vivo. The time-dependent expression of IFNAR was supported by that of transcription factor level induced by interferon-β. The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells.

Original languageEnglish
Pages (from-to)1449-1455
Number of pages7
JournalLife Sciences
Volume68
Issue number12
DOIs
Publication statusPublished - Feb 9 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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